DNA2 Antibodies

AND DNA2 ELISA kits, DNA2 Proteins

Many biological assays use antibodies to detect DNA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DNA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DNA2 antibodies...

We validate the specificity of these antibodies to DNA2 by testing them on tissues known to express DNA2 positively and negatively. Browse below to find the DNA2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DNA2 Infographic by Boster Bio

All DNA2 Products

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Product

Figures

Specificity

Applications

Price

Anti-DNA2 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A01526
100ul

DNA2 (NM_001080449) Human Over-expression Lysate

Human

$960
Cat # LS001763
100 µg

DNA2 Overview

Facts about DNA replication ATP-dependent helicase/nuclease DNA2.

DNA2 3D structure. Source: alphafold

DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)

Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps which are more than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 that cleaves the flap until it's too brief to bind RPA and becomes a substrate for FEN1. Also included in 5'-end resection of DNA during double- strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.

Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities.

Gene Information

Human
Gene Name:	DNA2
Uniprot:	P51530
Entrez:	1763

Family

Belongs to:

DNA2/NAM7 helicase family

Alternative Names

DNA replication ATP-dependent helicase-like homolog; DNA replication helicase 2 homolog (yeast); DNA2 DNA replication helicase 2-like (yeast); EC 3.6.1; EC 3.6.4.12; FLJ10063; KIAA0083DNA2LDNA2-like helicase; MGC133297

Molecular Weight

Mass (kDA):
120.415 kDA

Genomic Context


Human

Location:	10q21.3
Sequence:	10; NC_000010.11 (68414064..68472521, complement)

Subcellular Localizations

Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465).