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Dematin Antibodies
AND DMTN ELISA kits, Dematin Proteins
Many biological assays use antibodies to detect Dematin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dematin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dematin antibodies...
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DMTN Infographic by Boster Bio
All DMTN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1169
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1169
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2249
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2249
1 kit, containing two 96-well plates and all necessary reagents
DMTN Overview
Facts about Dematin.
Dematin (DMTN)
Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling action is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA).
Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties.
Gene Information
| Human | |
|---|---|
| Gene Name: | DMTN |
| Uniprot: | Q08495 |
| Entrez: | 2039 |
Family
| Belongs to: |
|---|
| villin/gelsolin family |
Alternative Names
Dematin
Molecular Weight
Mass (kDA):
45.514 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (22048931..22082527) |
Tissue Specificity
Expressed in platelets (at protein level). Expressed in heart, brain, lung, skeletal muscle, and kidney.
Subcellular Localizations
Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.
Interacting Proteins
- GOLGA2
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DMTN
bosterbio.com/bosterbio-gene-info-cards/DMTN
References
PMID: 8341682 by Rana A.P., et al. Cloning of human erythroid dematin reveals another member of the villin family.
PMID: 7615546 by Azim A.C., et al. Isoform cloning, actin binding, and chromosomal localization of human erythroid dematin, a member of the villin superfamily.