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DLST Antibodies
AND DLST ELISA kits, DLST Proteins
Many biological assays use antibodies to detect DLST, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DLST in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DLST antibodies...
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DLST Infographic by Boster Bio
All DLST Products
Product
Figures
Specificity
Applications
Price
Human
WB
$250
Cat # PROTP36957
2ug, 10ug, 1mg
Cat # PROTP36957
2ug, 10ug, 1mg
DLST Overview
Facts about Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial.
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST)
Dihydrolipoamide succinyltransferase (E2) component of this 2-oxoglutarate dehydrogenase complex (By similarity). The 2- oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate into succinyl-CoA and CO(2) (By similarity).
The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of this 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is necessary for lysine succinylation of histones: partners with KAT2A on chromatin and supplies succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).
Gene Information
| Human | |
|---|---|
| Gene Name: | DLST |
| Uniprot: | P36957 |
| Entrez: | 1743 |
Family
| Belongs to: |
|---|
| 2-oxoacid dehydrogenase family |
Alternative Names
2-oxoglutarate dehydrogenase complex component E2; dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutaratecomplex); Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenasecomplex; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutaratedehydrogenase complex, mitochondrial; DLTS; E2K; EC 2.3.1; EC 2.3.1.61; OGDC-E2
Molecular Weight
Mass (kDA):
48.755 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q24.3 |
| Sequence: | 14; NC_000014.9 (74881913..74903743) |
Subcellular Localizations
Mitochondrion matrix. Nucleus. Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Diseases
- Pneumonia
- Allergy
- Pneumonia, Interstitial
- Lung Diseases, Interstitial
- Dyspnea
- Alzheimer's Disease
- Exanthema
- Coughing
- Lung Injury
- Injury To Liver
- Malignant Neoplasms
- Tuberculosis
- Drug Eruptions
Interacting Proteins
- CDK1
- NAP1L1
- YWHAE
Pathways
- Hypersensitivity
- Pathogenesis
- Leukocyte Migration
- Anaphylaxis
- Glycolysis
- Transport
- Cell Proliferation
- Tricarboxylic Acid Cycle
- Electron Transport
- Aging
- Electron Transport Chain
- Oxidative Phosphorylation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLST
bosterbio.com/bosterbio-gene-info-cards/DLST
References
PMID: 8268217 by Nakano K., et al. Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.
PMID: 8076640 by Nakano K., et al. Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex.