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Disks large homolog 4 Antibodies
AND DLG4 ELISA kits, Disks large homolog 4 Proteins
Many biological assays use antibodies to detect Disks large homolog 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Disks large homolog 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Disks large homolog 4 antibodies...
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DLG4 Infographic by Boster Bio
All DLG4 Products
Product
Figures
Specificity
Applications
Price
Anti-PSD95/DLG4 Antibody Picoband®
2 Citations 1 Q&As
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # PB9802
100 μg/vial
Cat # PB9802
100 μg/vial
Human, Mouse, Rat
IF, IHC, WB
$370
Cat # PA2295
100 μg/vial
Cat # PA2295
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02128
100 μl
Cat # M02128
100 μl
Human, Mouse
IHC, WB
$431
Cat # M02128-1
100uL
Cat # M02128-1
100uL
Anti-PSD95/DLG4 Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02128
100 μg/vial
Cat # A02128
100 μg/vial
DLG4 Overview
Facts about Disks large homolog 4.
Disks large homolog 4 (DLG4)
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling.
Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by keeping the station intracellularly.
Gene Information
| Human | |
|---|---|
| Gene Name: | DLG4 |
| Uniprot: | P78352 |
| Entrez: | 1742 |
Family
| Belongs to: |
|---|
| MAGUK family |
Alternative Names
discs, large homolog 4 (Drosophila); disks large homolog 4; DLG4; FLJ97752; FLJ98574; Postsynaptic density protein 95; post-synaptic density protein 95; PSD95; PSD-95; PSD95SAP90SAP-90discs large homolog 4; SAP90; Synapse-associated protein 90; Tax interaction protein 15
Molecular Weight
Mass (kDA):
80.495 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7187180..7220050, complement) |
Tissue Specificity
Brain.
Subcellular Localizations
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cytoplasm. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cell junction, synapse, presynapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Diseases
- Schizophrenia
- Alzheimer's Disease
- Neoplasms
- Depressive Disorder
- Major Depressive Disorder
- Nervousness
- Bipolar Disorder
- Impaired Cognition
- Tissue Adhesions
- Dementia
- Malignant Neoplasms
- Neuropathology Disease
Interacting Proteins
- CRIPT
- DLGAP1
- ERBB4
- Gpsm2
- GRIN2A
- GRIN2B
- GRIN2C
- KCNA1
- Kcna1
- Kcna2
Pathways
- Localization
- Pathogenesis
- Translation
- Synaptic Transmission
- Neurogenesis
- Cell Division
- Cell Adhesion
- Aging
- Brain Development
- Asymmetric Cell Division
- Cognition
- Signal Transmission
- Endocytosis
PTMs
- Phosphorylation
- Oxidation
- Dephosphorylation
Research Areas
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLG4
bosterbio.com/bosterbio-gene-info-cards/DLG4
References
PMID: 9286702 by Stathakis D.G., et al. Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues.
PMID: 10582582 by Stathakis D.G., et al. Genomic organization of human DLG4, the gene encoding postsynaptic density 95.
3 Publications of Boster Disks large homolog 4 Antibodies & ELISA Kits
- PubMed ID: 10.1016/j.bbrc.2017.06.108, Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmenta...
- PubMed ID: 10.1016/j.bbr.2020.113085, Intensive treadmill training promotes cognitive recovery after cerebral ischemia...
- PubMed ID: -, Ou Qiao,Xinyu Zhang,Yi Zhang et al.Cerebralcare Granule® enhances memantine hyd...
*More publications can be found for each product on its corresponding product page