DKC1 Antibodies

AND DKC1 ELISA kits, DKC1 Proteins

Many biological assays use antibodies to detect DKC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DKC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DKC1 antibodies...

We validate the specificity of these antibodies to DKC1 by testing them on tissues known to express DKC1 positively and negatively. Browse below to find the DKC1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DKC1 Infographic by Boster Bio

All DKC1 Products

Product

Figures

Specificity

Applications

Price

Anti-Dyskerin DKC1 Antibody

7 Q&As

Human, Mouse, Rat

IF, WB

$360
Cat # A01535-1
100 µl

Dyskerin Colorimetric Cell-Based ELISA

Human, Mouse, Rat

ELISA

$480
Cat # EKC1643
1 kit, containing one 96-well plate and all necessary reagents

Anti-DKC1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M01535-1
100 μl/vial

DKC1 (NM_001363) Human Over-expression Lysate

Human

$628
Cat # LS001736
100 µg

DKC1 Overview

Facts about H/ACA ribonucleoprotein complex subunit DKC1.

DKC1 3D structure. Source: alphafold

H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

Isoform 1: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674).

Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674).

Gene Information

Human
Gene Name:	DKC1
Uniprot:	O60832
Entrez:	1736

Family

Belongs to:

pseudouridine synthase TruB family

Alternative Names

CBF5 homolog; CBF5; cbf5p homolog; DKC; dyskeratosis congenita 1, dyskerin; Dyskerin; EC 5.4.99; EC 5.4.99.-; FLJ97620; H/ACA ribonucleoprotein complex subunit 4; NAP57; NOLA4dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein family A member 4; Nucleolar protein NAP57; snoRNP protein DKC1; XAP101

Molecular Weight

Mass (kDA):
57.674 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (154762742..154777689)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

[Isoform 1]: Nucleus, nucleolus. Nucleus, Cajal body. Also localized to Cajal bodies (coiled bodies).; [Isoform 3]: Cytoplasm.

Diseases

Dyskeratosis Congenita
Dyskeratosis
Malignant Neoplasms
Pancytopenia
X-linked Dyskeratosis Congenita
Anemia
Aplastic Anemia
Neoplasms
Leukoplakia
Telomere Shortening
Dystrophy
Dystrophia Unguium

Premature Aging Syndrome
Inherited Bone Marrow Failure Syndrome
Fibrosis
Malignant Paraganglionic Neoplasm
Bone Marrow Diseases
Dysmyelopoietic Syndromes

Interacting Proteins

HMBOX1
NAF1
RUVBL1
SHQ1

Pathways

Telomere Maintenance
Pigmentation
Pathogenesis
Aging
Senescence
Ribosome Biogenesis
Cell Proliferation
Rna Processing
Translation
Localization
Rna Modification
Cell Cycle
Cell Death

Rrna Processing
Methylation
Cell Division
Dna Repair
Transport
Cellular Senescence
Cell Cycle Arrest

PTMs

Methylation
Phosphorylation
Sumoylation

Reduction
Cleavage
Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DKC1

References

PMID: 9590285 by Heiss N.S., et al. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions.

PMID: 10364516 by Knight S.W., et al. X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene.