Thyroxine 5-deiodinase Antibodies

AND DIO3 ELISA kits, Thyroxine 5-deiodinase Proteins

Many biological assays use antibodies to detect Thyroxine 5-deiodinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Thyroxine 5-deiodinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Thyroxine 5-deiodinase antibodies...

We validate the specificity of these antibodies to Thyroxine 5-deiodinase by testing them on tissues known to express DIO3 positively and negatively. Browse below to find the DIO3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Anti-Thyroxine 5-deiodinase DIO3 Antibody

4 Q&As

Human, Mouse, Rat

$399
Cat # A02903
100μl

DIO3 Overview

Facts about Thyroxine 5-deiodinase.

Thyroxine 5-deiodinase (DIO3)

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) to T2 (3,3'-diiodothyronine).
RT3 and T2 are inactive metabolites.

May play a role in preventing premature exposure of developing fetal cells to mature levels of thyroid hormones. Can modulate circulating fetal thyroid hormone concentrations throughout gestation.

Gene Information

Human
Gene Name:	DIO3
Uniprot:	P55073
Entrez:	1735

Family

Belongs to:

iodothyronine deiodinase family

Alternative Names

5DIII; D3; deiodinase, iodothyronine, type III; DIOIII; EC 1.97.1; EC 1.97.1.11; ITDI3; placental type; thyroxine deiodinase type III (selenoprotein); Type 3 DI; type 3 iodothyronine selenodeiodinase; type III iodothyronine deiodinase; type-III 5' deiodinase; Type-III 5'-deiodinase

Molecular Weight

Mass (kDA):
33.947 kDA

Genomic Context


Human

Location:	14q32.31
Sequence:	14; NC_000014.9 (101561351..101563452)

Tissue Specificity

Expressed in placenta and several fetal tissues.

Subcellular Localizations

Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.

Diseases

Pituitary Diseases
Uniparental Disomy
Hypothyroidism
Hypertrophy
Malignant Neoplasms
Heart Failure
Hypoxia
Neoplasms
Thyrotoxicosis
Ischemia

Degenerative Polyarthritis
Complete Hearing Loss
Neoplasm Metastasis
Right Ventricular Hypertrophy
Congenital Musculoskeletal Anomalies

Pathways

Methylation
Secretion
Brain Development
Cell Proliferation
Dna Methylation
Transport
Regulation Of Gene Expression
Ossification
Localization
Cell Migration
Dna Hypermethylation
Developmental Process
Fertilization

Aging
Pigmentation
Hypersensitivity
Spermatogenesis
Glucose Homeostasis
Translation
Cell Cycle

PTMs

Methylation
Deiodination
Carboxylation

Cleavage
Bromination
Ubiquitination

Research Areas

Cancer
Growth and Development
Lipid and Metabolism
Neuroscience
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DIO3

References

PMID: 7593630 by Salvatore D., et al. Type 3 iodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme.

PMID: 12746313 by Kuiper G.G., et al. Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference.