DIO1 Antibodies

AND DIO1 ELISA kits, DIO1 Proteins

Many biological assays use antibodies to detect DIO1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DIO1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DIO1 antibodies...

We validate the specificity of these antibodies to DIO1 by testing them on tissues known to express DIO1 positively and negatively. Browse below to find the DIO1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DIO1 Infographic by Boster Bio

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Anti-DIO1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A04612
100 μg/vial

DIO1 Overview

Facts about Type I iodothyronine deiodinase.

Type I iodothyronine deiodinase (DIO1)

Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).
Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues like liver and kidney.

Gene Information

Human
Gene Name:	DIO1
Uniprot:	P49895
Entrez:	1733

Family

Belongs to:

iodothyronine deiodinase family

Alternative Names

5DI; deiodinase, iodothyronine, type I; DIOI; EC 1.97.1; EC 1.97.1.10; ITDI1; MGC130050; thyroxine deiodinase type I (selenoprotein); TXDI1MGC130051; Type 1 DI; type I iodothyronine deiodinase; Type-I 5'-deiodinase

Molecular Weight

Mass (kDA):
28.924 kDA

Genomic Context


Human

Location:	1p32.3
Sequence:	1; NC_000001.11 (53894187..53911086)

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Pituitary Diseases
Carcinoma
Hypothyroidism
Thyroid Neoplasm
Thyroid Diseases
Kidney Neoplasm
Malignant Paraganglionic Neoplasm
Hyperthyroidism
Adenoma
Renal Cell Carcinoma

Follicular Adenoma
Fatty Liver
Follicular Thyroid Carcinoma
Conventional (clear Cell) Renal Cell Carcinoma
Heart Diseases
Depressive Disorder

Pathways

Cell Proliferation
Secretion
Transport
Lactation
Regulation Of Gene Expression
Translation
Pathogenesis
Developmental Process
Parturition
Brain Development
Aging
Glycosylation

Pigmentation
Glucose Homeostasis
Dna Replication
Hatching
Rna Interference
Excretion
Chromatin Remodeling

PTMs

Deiodination
Phosphorylation
Carboxylation

Glycosylation
Acetylation
Bromination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DIO1

References

PMID: 1400883 by Mandel S.J., et al. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase.

PMID: 7651427 by Toyoda N., et al. A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene.