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Dhx36 Antibodies
AND Dhx36 ELISA kits, Dhx36 Proteins
Many biological assays use antibodies to detect Dhx36, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dhx36 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dhx36 antibodies...
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Dhx36 Overview
Facts about ATP-dependent DNA/RNA helicase DHX36.
ATP-dependent DNA/RNA helicase DHX36 (Dhx36)
Proposed to have an international role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures.
Binds to quadruplex structures in the promoters of both YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an inner quadruplex formation in TERC 5'-end to market P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is interrupted by quadruplex formation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Dhx36 |
| Uniprot: | Q8VHK9 |
| Entrez: | 72162 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
DDX36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; DEAH box protein 36; EC 3.6.1; EC 3.6.4.13; G4 resolvase-1; KIAA1488G4R1; MLEL1RHAUDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; MLE-like protein 1; probable ATP-dependent RNA helicase DHX36; RNA helicase associated with AU-rich element ARE
Molecular Weight
Mass (kDA):
113.883 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3|3 E1 |
| Sequence: | 3; |
Diseases
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Radiation Chimera Disorder
- Anemia
- Malignant Neoplasm Of Breast
- Hepatitis
- Communicable Diseases
- Ataxia
- Malignant Neoplasm Of Liver
- Leukopenia
- Hepatitis C
- Virus Diseases
Pathways
- Localization
- Translation
- Telomere Maintenance
- Spermatogenesis
- Regeneration
- Reverse Transcription
- Regulation Of Gene Expression
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dhx36
bosterbio.com/bosterbio-gene-info-cards/Dhx36
References
PMID: 12198572 by Fu J.-J., et al. Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily.
PMID: 21703541 by Zhang Z., et al. DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells.