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Derlin-1 Antibodies
AND Derl1 ELISA kits, Derlin-1 Proteins
Many biological assays use antibodies to detect Derlin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Derlin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Derlin-1 antibodies...
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Derl1 Overview
Facts about Derlin-1.
Derlin-1 (Derl1)
Functional part of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel which allows the retrotranslocation of misfolded proteins to the cytosol where they are ubiquitinated and degraded by the proteasome.
May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins to the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Derl1 |
| Uniprot: | Q99J56 |
| Entrez: | 67819 |
Family
| Belongs to: |
|---|
| derlin family |
Alternative Names
DER-1; DER1Degradation in endoplasmic reticulum protein 1; Der1-like domain family, member 1; Der1-like protein 1; derlin-1; DERtrin-1; FLJ13784; FLJ42092; MGC3067; PRO2577
Molecular Weight
Mass (kDA):
28.835 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15|15 D1 |
| Sequence: | 15; |
Tissue Specificity
Widely expressed, with lowest levels in brain and heart.
Diseases
- Dislocations
- Neoplasms
- Malignant Neoplasms
- Cytomegalovirus Infections
- Aortic Aneurysm, Abdominal
- Cystic Fibrosis
- Carcinoma
- Fibrosis
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasm Of Breast
- Endoplasmic Reticulum Stress
Pathways
- Transport
- Rna Interference
- Secretory Pathway
- Proteolysis
- Secretion
- Cell Proliferation
- Insulin Secretion
- Glycosylation
- Neuron Death
PTMs
- Glycosylation
- Ubiquitination
Research Areas
- ER Markers
- Immunology
- Lipid and Metabolism
- Protein Turnover
- Signal Transduction
- Unfolded Protein Response
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Derl1
bosterbio.com/bosterbio-gene-info-cards/Derl1
References
PMID: 16186509 by Lilley B.N., et al. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
PMID: 16449189 by Oda Y., et al. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.