Def6 Antibodies

AND Def6 ELISA kits, Def6 Proteins

Many biological assays use antibodies to detect Def6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Def6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Def6 antibodies...

We validate the specificity of these antibodies to Def6 by testing them on tissues known to express Def6 positively and negatively. Browse below to find the Def6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Def6 Infographic by Boster Bio

All Def6 Products

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Product

Figures

Specificity

Applications

Price

DEF6 (NM_022047) Human Recombinant Protein

$1062
Cat # PROTQ9H4E7
20 µg

Anti-DEF6 Mouse Monoclonal Antibody [Clone ID: OTI1E3]

Dog, Human, Monkey, Mouse, Rat

IF, IHC, WB

$523
Cat # M06058
100 µl

DEF6 (NM_022047) Human Over-expression Lysate

Human

$960
Cat # LS050619
100 µg

Def6 Overview

Facts about Differentially expressed in FDCP 6.

Differentially expressed in FDCP 6 (Def6)

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in collaboration with activated RAC1.

Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimum T-cell effector function, lymphocyte homeostasis and the avoidance of systemic autoimmunity (By similarity).

Gene Information

Mouse
Gene Name:	Def6
Uniprot:	Q8C2K1
Entrez:	23853

Family

Belongs to:

No superfamily

Alternative Names

DEF-6; differentially expressed in FDCP 6 homolog (mouse); differentially expressed in FDCP 6 homolog; IBPdifferentially expressed in FDCP (mouse homolog) 6; IRF4-binding protein; SLAT; SWAP70L; SWAP-70-like adaptor protein of T cells

Molecular Weight

Mass (kDA):
73.454 kDA

Genomic Context


Mouse

Location:	17\|17 A3.3
Sequence:	17;

Tissue Specificity

Thymus.

Diseases

Autoimmunity
Autoimmune Reaction
Autoimmune Diseases
Neoplasms
Lupus Erythematosus, Systemic
Experimental Autoimmune Encephalomyelitis
Inflammation
Malignant Neoplasms
Encephalomyelitis
Malignant Paraganglionic Neoplasm
Adenoma
Malignant Neoplasm Of Breast

Sarcoma
Carcinoma
Septic Shock
Chondrosarcoma
Papillary Adenocarcinoma
Innate Immune Response
Pertussis

Pathways

Cell Activation
T Cell Activation
Cell Proliferation
Pathogenesis
Localization
T Cell Proliferation
Cell Differentiation
Gastrulation
Convergent Extension
Cell Development
T Cell Homeostasis
Plasma Cell Differentiation
Lymphocyte Homeostasis

Immunological Synapse Formation
Cell Fate Specification
Phagocytosis
Translation
Cell Death
Regulation Of Cell Proliferation
Regulation Of T Cell Activation

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Def6

References

PMID: 12648457 by Tanaka Y., et al. SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells.

PMID: 12651066 by Gupta S., et al. Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.