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DDIT4 Antibodies
AND DDIT4 ELISA kits, DDIT4 Proteins
Many biological assays use antibodies to detect DDIT4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDIT4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDIT4 antibodies...
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DDIT4 Overview
Facts about DNA damage-inducible transcript 4 protein.
DNA damage-inducible transcript 4 protein (DDIT4)
Regulates cell growth, proliferation and survival through inhibition of the action of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway which involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB.
Plays an essential role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage through its effect on mTORC1 activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | DDIT4 |
| Uniprot: | Q9NX09 |
| Entrez: | 54541 |
Family
| Belongs to: |
|---|
| DDIT4 family |
Alternative Names
Dig2; DNA-damage-inducible transcript 4; FLJ20500; HIF-1 responsive RTP801 (RTP801); Protein regulated in development and DNA damage response 1; REDD-1DNA damage-inducible transcript 4 protein; REDD1HIF-1 responsive protein RTP801; RTP801RP11-442H21.1
Molecular Weight
Mass (kDA):
25.371 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q22.1 |
| Sequence: | 10; NC_000010.11 (72273924..72276036) |
Tissue Specificity
Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level).
Subcellular Localizations
Mitochondrion. Cytoplasm, cytosol.
Diseases
- Hypoxia
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Sclerosis
- Carcinoma
- Tuberous Sclerosis
- Anoxia
- Malignant Paraganglionic Neoplasm
- Myeloid Leukemia
- Mammary Neoplasms
- Physiological Stress
Pathways
- Cell Growth
- Translation
- Response To Hypoxia
- Cell Cycle
- Cell Death
- Cell Proliferation
- Senescence
- Neuron Death
- Response To Stress
- Dna Repair
- Energy Homeostasis
- Muscle Atrophy
- Pathogenesis
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Cancer
- mTOR Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDIT4
bosterbio.com/bosterbio-gene-info-cards/DDIT4
References
PMID: 12453409 by Ellisen L.W., et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.
PMID: 11884613 by Shoshani T., et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.