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DDB2 Antibodies
AND DDB2 ELISA kits, DDB2 Proteins
Many biological assays use antibodies to detect DDB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDB2 antibodies...
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DDB2 Infographic by Boster Bio
All DDB2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, ICC, WB
$405
Cat # A01430-1
100ul
Cat # A01430-1
100ul
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01430-1
100 μl/vial
Cat # M01430-1
100 μl/vial
DDB2 Overview
Facts about DNA damage-binding protein 2.
DNA damage-binding protein 2 (DDB2)
Needed for DNA repair.
Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex).The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches.
Gene Information
| Human | |
|---|---|
| Gene Name: | DDB2 |
| Uniprot: | Q92466 |
| Entrez: | 1643 |
Family
| Belongs to: |
|---|
| WD repeat DDB2/WDR76 family |
Alternative Names
damage-specific DNA binding protein 2 (48kD); damage-specific DNA binding protein 2, 48kDa; Damage-specific DNA-binding protein 2; DDB p48 subunit; DDB2; DDBB; DNA damage-binding protein 2; FLJ34321; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XP5; XPE/DDB2
Molecular Weight
Mass (kDA):
47.864 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (47214942..47239218) |
Tissue Specificity
Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed.
Subcellular Localizations
Nucleus. Accumulates at sites of DNA damage following UV irradiation.
Diseases
- Xeroderma Pigmentosum
- Xeroderma
- Malignant Neoplasms
- Neoplasms
- Xeroderma Pigmentosum, Group E
- Skin Neoplasms
- Malignant Neoplasm Of Skin
- Carcinogenesis
- Cockayne Syndrome
- Xeroderma Pigmentosum Complementation Group A
- Malignant Neoplasm Of Breast
- Carcinoma
Interacting Proteins
- CUL4A
- DDB1
- E2F1
Pathways
- Dna Repair
- Cell Cycle
- Localization
- Cell Death
- Proteolysis
- Response To Uv
- Cell Growth
- Chromatin Remodeling
- S Phase
- Cell Cycle Arrest
- Dna Replication
- Aging
- Senescence
PTMs
- Ubiquitination
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDB2
bosterbio.com/bosterbio-gene-info-cards/DDB2
References
PMID: 8530102 by Dualan R., et al. Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
PMID: 14751237 by Inoki T., et al. Human DDB2 splicing variants are dominant negative inhibitors of UV- damaged DNA repair.