DDB1 Antibodies

DNA damage-binding protein 1 (DDB1)

Needed for DNA repair.

Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complicated ).

The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as a component of many distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Information

Human
Gene Name:	DDB1
Uniprot:	Q16531
Entrez:	1642

Family

Belongs to:
DDB1 family

Alternative Names

damage-specific DNA binding protein 1 (127kD); damage-specific DNA binding protein 1, 127kDa; Damage-specific DNA-binding protein 1; DDB p127 Subunit; DDB1; DDBA; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; XAP1; XAP-1; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE-BF; XPE-binding factor

Molecular Weight

Mass (kDA):
126.968 kDA

Genomic Context

Human
Location:	11q12.2
Sequence:	11; NC_000011.10 (61299451..61333105, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.

Diseases

• Xeroderma Pigmentosum
• Xeroderma
• Malignant Neoplasms
• Xeroderma Pigmentosum, Group E
• Neoplasms
• Hepatitis B
• Hepatitis
• Immunologic Deficiency Syndromes
• Hiv Infections
• Cockayne Syndrome
• Malignant Neoplasm Of Liver
• Carcinoma

• Genomic Instability
• Virus Diseases
• Malignant Neoplasm Of Skin
• Hereditary Diseases
• Carcinogenesis
• Liver Carcinoma

Interacting Proteins

• ACTR5
• CRBN
• CUL4A
• CUL4B
• DCAF1

• DCAF11
• DCAF4
• DCAF8
• DDB2
• DTL

• EED
• INO80
• STAT1
• TLE2

Pathways

• Cell Cycle
• Dna Repair
• Proteolysis
• Dna Replication
• S Phase
• Localization
• Cell Cycle Arrest
• Methylation
• Rna Interference
• Cell Growth
• Mitosis
• Cell Proliferation
• Gene Silencing

• Response To Uv
• Viral Replication
• Cell Division
• Pathogenesis
• Photomorphogenesis
• Reverse Transcription
• G1 Phase

PTMs

• Ubiquitination
• Phosphorylation

• Methylation
• Reduction

• Cleavage

Research Areas

• DNA Repair
• Nucleotide Excision Repair

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDB1

Boster Bio - Best Uses Of The DDB1 Marker

Boster Bio offers a DDB1 marker for those looking for a new antibody or to help determine if an existing antibody is suitable for their experiment. They offer a variety of different products to pick from, including Super Vision Detection Kits and Picokine ELISA platforms. This article will concentrate on the DDB1 marker's advantages.

Boster Bio's Picokine ELISA platform

The Picokine ELISA platform from Boster Bio is a multi-functional and effective instrument for detecting the DDB1 marker. Its unique, high-affinity antibodies allow for supreme sensitivity in detection. Picokine ELISA has been validated using more than 25,000 samples taken from more than 250 different types of tissue. In addition, it's compatible with WB, Flow Cytometry, and IHC.

The Picokine(tm) ELISA platform is an immunoassay in solid phase that utilizes micro-titration wells to detect DDB1 in a variety of biological samples. Picokine(tm) is a method which increases sensitiveness and decreases non-specific binding, reduces the amount of capture antibodies. The sensitivity of the Picogram is attained and high specificity is achieved. PicoKine(r) Quick ELISA is tested on a broad range of biological samples and allows an extensive range of target analytes.

The PicoKine(tm) ELISA kit contains the kit with 96 wells. It comes with strips that can be removed to allow for easy sampling. This kit can be used with various biological samples and will react with the target analyte. This Picokine(r) Quick ELISA Kit is easy inexpensive, efficient, and practical. Picokine(tm) is an ELISA kit created by bioinnovators is now available through tebubio.

Boster Bio's Super Vision Detection kits

Steven Xia, a high-specificity and highly sensitive antibody specialist established Boster Bio in 1993. Since then, he has spent more than two decades perfecting his technology and techniques, producing antibodies that have been cited in more than 29,000 scientific papers. All Boster Bio antibodies are standardized for ELISA, IHC, and WB applications, which guarantees their high sensitivity and specificity.