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DDB1 Antibodies
AND DDB1 ELISA kits, DDB1 Proteins
Many biological assays use antibodies to detect DDB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DDB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DDB1 antibodies...
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DDB1 Infographic by Boster Bio
All DDB1 Products
Product
Figures
Specificity
Applications
Price
Anti-DDB1 Antibody Picoband®
5 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9578
100 μg/vial
Cat # PB9578
100 μg/vial
DDB1 Overview
Facts about DNA damage-binding protein 1.
DNA damage-binding protein 1 (DDB1)
Needed for DNA repair.
Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complicated ).The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as a component of many distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | DDB1 |
| Uniprot: | Q16531 |
| Entrez: | 1642 |
Family
| Belongs to: |
|---|
| DDB1 family |
Alternative Names
damage-specific DNA binding protein 1 (127kD); damage-specific DNA binding protein 1, 127kDa; Damage-specific DNA-binding protein 1; DDB p127 Subunit; DDB1; DDBA; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; XAP1; XAP-1; Xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE-BF; XPE-binding factor
Molecular Weight
Mass (kDA):
126.968 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q12.2 |
| Sequence: | 11; NC_000011.10 (61299451..61333105, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.
Diseases
- Xeroderma Pigmentosum
- Xeroderma
- Malignant Neoplasms
- Xeroderma Pigmentosum, Group E
- Neoplasms
- Hepatitis B
- Hepatitis
- Immunologic Deficiency Syndromes
- Hiv Infections
- Cockayne Syndrome
- Malignant Neoplasm Of Liver
- Carcinoma
Interacting Proteins
- ACTR5
- CRBN
- CUL4A
- CUL4B
- DCAF1
- DCAF11
- DCAF4
- DCAF8
- DDB2
- DTL
Pathways
- Cell Cycle
- Dna Repair
- Proteolysis
- Dna Replication
- S Phase
- Localization
- Cell Cycle Arrest
- Methylation
- Rna Interference
- Cell Growth
- Mitosis
- Cell Proliferation
- Gene Silencing
PTMs
- Ubiquitination
- Phosphorylation
Research Areas
- DNA Repair
- Nucleotide Excision Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DDB1
bosterbio.com/bosterbio-gene-info-cards/DDB1
References
PMID: 8530102 by Dualan R., et al. Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
PMID: 7815490 by Lee T.H., et al. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.