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DCX Antibodies
AND DCX ELISA kits, DCX Proteins
Many biological assays use antibodies to detect DCX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DCX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DCX antibodies...
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DCX Infographic by Boster Bio
All DCX Products
Product
Figures
Specificity
Applications
Price
Anti-Doublecortin/DCX Antibody Picoband®
2 Citations 16 Q&As
Human, Mouse, Rat
WB
$370
Cat # A01053-1
100 μg/vial
Cat # A01053-1
100 μg/vial
Anti-DCX/Doublecortin Rabbit Monoclonal Antibody
2 Citations 3 Q&As
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M01053
100 μl
Cat # M01053
100 μl
Anti-Doublecortin/DCX Monoclonal Antibody
1 Citations 17 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$299
Cat # M01053-1
100ul
Cat # M01053-1
100ul
Human, Mouse, Rat
ELISA
$480
Cat # EKC1174
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1174
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IHC
$380
Cat # A01053S339
100ul
Cat # A01053S339
100ul
Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M01053-2
100 µl
Cat # M01053-2
100 µl
DCX Overview
Facts about Neuronal migration protein doublecortin.
Neuronal migration protein doublecortin (DCX)
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein.
May in that way take part in a signaling pathway that is crucial for neuronal interaction before and during migration, maybe as part of a calcium ion-dependent signal transduction pathway. May be a part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | DCX |
| Uniprot: | O43602 |
| Entrez: | 1641 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DBCN; Doublecortex; Doublecortin; Doublin; FLJ51296; Lissencephalin-X; LISX; Lis-X; X-linked (doublecortin)
Molecular Weight
Mass (kDA):
40.574 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq23 |
| Sequence: | X; NC_000023.11 (111293779..111412205, complement) |
Tissue Specificity
Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.
Subcellular Localizations
Cytoplasm. Cell projection, neuron projection. Localizes at neurite tips.
Diseases
- Lissencephaly
- Epilepsy
- Ectopic Tissue
- Subcortical Band Heterotopia
- Ischemia
- Cerebrovascular Accident
- Brain Ischemia
- Nervousness
- Neuronal Migration Disorders
- Brain Injuries
- Arterial Occlusion
Interacting Proteins
- CALCOCO2
- GOLGA2
- IKZF1
- KIFC3
- KRT40
- KRTAP10-8
- MEOX1
- RINT1
- SPAG5
- TINF2
Pathways
- Neurogenesis
- Cell Proliferation
- Neuroblast Differentiation
- Cell Adhesion
- Brain Development
- Cell Migration
- Cell Cycle
- Cell Death
- Aging
- Pathogenesis
- Localization
- Neuroprotection
- Angiogenesis
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCX
bosterbio.com/bosterbio-gene-info-cards/DCX
References
PMID: 9489699 by Des Portes V., et al. A novel CNS gene required for neuronal migration and involved in X- linked subcortical laminar heterotopia and lissencephaly syndrome.
PMID: 9489700 by Gleeson J.G., et al. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.
2 Publications of Boster DCX Antibodies & ELISA Kits
- PubMed ID: 21699735, Zhang Xm, Du F, Yang D, Wang R, Yu Cj, Huang Xn, Hu Hy, Liu W, Fu J. Bmc Neurosc...
- PubMed ID: 20973978, Zhang Xm, Du F, Yang D, Yu Cj, Huang Xn, Liu W, Fu J. Bmc Neurosci. 2010 Oct 25;...
*More publications can be found for each product on its corresponding product page