m7GpppN-mRNA hydrolase Antibodies

m7GpppN-mRNA hydrolase (Dcp2)

Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (PubMed:21070968).

Necessary for the degradation of mRNAs, both in ordinary mRNA turnover and in nonsense-mediated mRNA decay (By similarity). Plays a role in replication-dependent histone mRNA degradation (By similarity).

Gene Information

Mouse
Gene Name:	Dcp2
Uniprot:	Q9CYC6
Entrez:	70640

Family

Belongs to:
Nudix hydrolase family

Alternative Names

DCP2 decapping enzyme homolog (S. cerevisiae); EC 3.-; FLJ33245; hDpc; mRNA-decapping enzyme 2; nudix (nucleoside diphosphate linked moiety X)-type motif 20; Nudix motif 20; NUDT20Nucleoside diphosphate-linked moiety X motif 20

Molecular Weight

Mass (kDA):
48.38 kDA

Genomic Context

Mouse
Location:	18|18 B3
Sequence:	18;

Tissue Specificity

Strongly expressed in brain and testis. Weakly expressed in lung. Not detected in heart, liver, kidney and muscle (at protein level).

Diseases

• Physiological Stress
• Hepatitis
• Malignant Neoplasms
• Hepatitis C
• Hiv Infections
• Acquired Immunodeficiency Syndrome
• Colonic Neoplasms
• Malignant Tumor Of Colon
• Hepatitis B
• Immunologic Deficiency Syndromes
• Tumor Angiogenesis

• Innate Immune Response
• Lymphoma
• Transient Ischemic Attack
• Lentivirus Infections
• Biliary Cirrhosis

Pathways

• Translation
• Localization
• Mrna Processing
• Gene Silencing
• Transport
• Regulation Of Gene Expression
• Response To Heat
• Mrna Stabilization
• Regulation Of Mrna Stability
• Rna Interference
• Programmed Cell Death
• Immune Response
• Stress Granule Assembly

• Nuclear Export
• Tissue Development
• Reverse Transcription
• Karyogamy
• Innate Immune Response
• Seed Germination
• Mating

PTMs

• Cleavage

• Phosphorylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Dcp2

Boster Bio - Best Uses Of The DCP2 Marker

There are many options to choose from when optimizing your experiments with Boster Bio. You will find optimization guides and tips to help you optimize your experiments. Here are some common questions and their answers.

m7GpppN RNA hydrolase antibodies

Steven E. Boster PhD, the inventor of the Boster Bio M7Gppp-RNA Hydrolase antibody, was a man who "converts science in a lavatory". He began developing products in 1993 and quickly became China's largest antibody catalog. Boster created PicoKine(tm) a proprietary ELISA platform in the late 1990s. PicoKineTM platform leveraged trade secrets for high-sensitivity ELISA Kits.