This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about mRNA-decapping enzyme 1A.
Contributes to the transactivation of target genes after stimulation by TGFB1. .
Human | |
---|---|
Gene Name: | DCP1A |
Uniprot: | Q9NPI6 |
Entrez: | 55802 |
Belongs to: |
---|
DCP1 family |
DCP1 decapping enzyme homolog A (S. cerevisiae); decapping enzyme hDcp1a; EC 3.-; FLJ21691; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIFHSA275986; Transcription factor SMIF
Mass (kDA):
63.278 kDA
Human | |
---|---|
Location: | 3p21.1 |
Sequence: | 3; NC_000003.12 (53283429..53347543, complement) |
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Cytoplasm, P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524).
PMID: 12417715 by Lykke-Andersen J.; Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.
PMID: 11836524 by Bai R.-Y., et al. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling.