Lariat debranching enzyme Antibodies

AND DBR1 ELISA kits, Lariat debranching enzyme Proteins

Many biological assays use antibodies to detect Lariat debranching enzyme, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lariat debranching enzyme in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lariat debranching enzyme antibodies...

We validate the specificity of these antibodies to Lariat debranching enzyme by testing them on tissues known to express DBR1 positively and negatively. Browse below to find the DBR1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DBR1 Infographic by Boster Bio

All DBR1 Products

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Specificity

Applications

Price

Human DBR1 Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ9UK59
Starting from 10ug

DBR1 (NM_016216) Human Over-expression Lysate

Human

$628
Cat # LS051163
100 µg

DBR1 Overview

Facts about Lariat debranching enzyme.

DBR1 3D structure. Source: alphafold

Lariat debranching enzyme (DBR1)

Cleaves the two'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules which are subsequently degraded. It thereby facilitates ribonucleotide turnover.

It may also take part in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. .

Gene Information

Human
Gene Name:	DBR1
Uniprot:	Q9UK59
Entrez:	51163

Family

Belongs to:

lariat debranching enzyme family

Alternative Names

debranching enzyme (S. Cerevisiae) homolog 1; debranching enzyme homolog 1 (S. cerevisiae); EC 3.1; lariat debranching enzyme; RNA lariat debranching enzyme

Molecular Weight

Mass (kDA):
61.555 kDA

Genomic Context


Human

Location:	3q22.3
Sequence:	3; NC_000003.12 (138160988..138174921, complement)

Subcellular Localizations

Nucleus.

Diseases

Sclerosis
Primary Lateral Sclerosis
Hypothyroidism
Hepatitis, Chronic
Hepatitis
Neurodegenerative Disorders
Hepatitis C, Chronic
Hepatitis C
Amyotrophic Lateral Sclerosis
Thyroiditis

Hyperthyroidism
Fibrosis
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Subacute Thyroiditis
Dysequilibrium Syndrome

Pathways

Transposition
Reverse Transcription
Regulation Of Defense Response
Regulation Of Defense Response To Virus
Myeloid Leukocyte Differentiation
Dna Repair
Immune Response
Response To Virus
Smoothened Signaling Pathway
Leukocyte Differentiation
Defense Response To Virus
Sporulation
Defense Response

Rna Splicing
Methylation
Filamentous Growth
Cell Growth
Invasive Growth
Cell Morphogenesis
Rna Processing

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DBR1

References

PMID: 10982890 by Kim J.-W., et al. Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants.

PMID: 2435736 by Arenas J., et al. Purification of a RNA debranching activity from HeLa cells.