Dynactin subunit 4 Antibodies

AND DCTN4 ELISA kits, Dynactin subunit 4 Proteins

Many biological assays use antibodies to detect Dynactin subunit 4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dynactin subunit 4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dynactin subunit 4 antibodies...

We validate the specificity of these antibodies to Dynactin subunit 4 by testing them on tissues known to express DCTN4 positively and negatively. Browse below to find the DCTN4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCTN4 Infographic by Boster Bio

All DCTN4 Products

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Anti-Dynactin subunit 4 DCTN4 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A10417
100ul

DCTN4 (NM_016221) Human Over-expression Lysate

Human

$628
Cat # LS051164
100 µg

DCTN4 Overview

Facts about Dynactin subunit 4.

DCTN4 3D structure. Source: alphafold

Dynactin subunit 4 (DCTN4)

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Gene Information

Human
Gene Name:	DCTN4
Uniprot:	Q9UJW0
Entrez:	51164

Family

Belongs to:

dynactin subunit 4 family

Alternative Names

dynactin 4 (p62); dynactin p62 subunit; dynactin subunit 4; Dynactin subunit p62

Molecular Weight

Mass (kDA):
52.337 kDA

Genomic Context


Human

Location:	5q33.1
Sequence:	5; NC_000005.10 (150708440..150759095, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere. Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By

Diseases

Cystic Fibrosis
Fibrosis
Hepatolenticular Degeneration
Pseudomonas Aeruginosa Infection
Pseudomonas Infections

Interacting Proteins

CALCOCO2
GOLGA2
MTUS2
PNMA1

PTMs

Acetylation
Isopeptide bond

Phosphoprotein
Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCTN4

References

PMID: 10671518 by Karki S., et al. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1.

PMID: 16554302 by Lim C.M., et al. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A.