Drebrin Antibodies

Drebrin (DBN1)

Drebrins may play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruiting to IS.

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Gene Information

Human
Gene Name:	DBN1
Uniprot:	Q16643
Entrez:	1627

Family

Belongs to:
No superfamily

Alternative Names

D0S117E; DBN1; Developmentally-regulated brain protein; DKFZp434D064; Drba; Drebrin 1; Drebrin A; Drebrin E; Drebrin E2; drebrin; drebrin-1

Molecular Weight

Mass (kDA):
71.429 kDA

Genomic Context

Human
Location:	5q35.3
Sequence:	5; NC_000005.10 (177456592..177480368, complement)

Subcellular Localizations

Cytoplasm. Cell projection, dendrite. Cytoplasm, cell cortex. Cell junction. Cell projection, growth cone. In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400). In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity).

Diseases

• Lung Injury
• Cell Transformation, Neoplastic
• Lung Neoplasms
• Respiratory Distress Syndrome, Newborn
• Non-small Cell Lung Carcinoma
• Tissue Adhesions
• Malignant Neoplasm Of Lung
• Respiratory Distress
• Fibrosis

• Malignant Neoplasms
• Neoplasms
• Lymphoma
• Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Interacting Proteins

• AFDN
• Afdn
• CXCR4
• GRB2
• GRN

• PTEN
• TINF2
• ZMYND8

Pathways

• Neurogenesis
• Cell Adhesion
• Actin Cytoskeleton Organization
• Cytoskeleton Organization
• Cell Proliferation
• Translation
• Tissue Remodeling
• Lung Development

• Rna Interference
• Myoblast Differentiation

PTMs

• Acetylation

• Phosphoprotein

Research Areas

• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DBN1

Boster Bio Anti-DBN1 Marker

If you're wondering what you can do with Boster Bio Anti-DBN1 antibodies, you've come to the right place. In this article, we'll look at the advantages of the DBN1 marker antibody and the best uses for it. This antibody was validated for use in Western Blotting, Immunohistochemistry, and ELISA. Its high affinity makes it an ideal choice for research projects requiring highly specific antibodies.

Boster Bio Anti-DBN1 Antibody

The Boster Bio Anti-DBN1 Antibodies are produced by immunizing rabbits with a synthetic peptide that corresponds to residues near the carboxy terminus of the mouse DBN1 protein. Once produced, the antibodies are purified by peptide affinity chromatography. They are suitable for ELISA, Western Blotting, and immunohistochemistry applications.

Boster Bio Anti-KHDRBS2 Antibody

Boster Bio has developed an antibody to detect Khdrbs2, a KH domain-containing RNA-binding, signal transduction-associated protein that regulates alternative splicing and is expressed in the body. It acts on mRNA splicing by binding to a purine-rich exonic enhancer. It is used in a variety of biological assays and has been cited extensively for its superior quality. It is available as a 100ul Liquid solution for easy use.

Boster Bio Anti-Bax (S4) Antibody

The DBN1 marker is the first part of the drebrin protein sequence. The drebrin gene encodes a protein that is thought to have developmental regulatory functions in the brain. Studies have found that decreasing drebrin protein levels are associated with Alzheimer's disease. The DBN1 gene has two alternative splice variants. In order to identify the right antibody for your experiments, you must first determine the target protein. The Boster Bio Anti-Bax (S4) Antibody has been validated against known positive and negative samples.