Disabled homolog 2 Antibodies

AND DAB2 ELISA kits, Disabled homolog 2 Proteins

Many biological assays use antibodies to detect Disabled homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Disabled homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Disabled homolog 2 antibodies...

We validate the specificity of these antibodies to Disabled homolog 2 by testing them on tissues known to express DAB2 positively and negatively. Browse below to find the DAB2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DAB2 Infographic by Boster Bio

All DAB2 Products

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Specificity

Applications

Price

Anti-DAB2 Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01546-3
100 μg/vial

DAB2 (NM_001343) Human Over-expression Lysate

Human

$628
Cat # LS001601
100 µg

DAB2 Overview

Facts about Disabled homolog 2.

DAB2 3D structure. Source: alphafold

Disabled homolog 2 (DAB2)

Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them into clathrin-coated pits.

Can operate in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1.

Gene Information

Human
Gene Name:	DAB2
Uniprot:	P98082
Entrez:	1601

Family

Belongs to:

No superfamily

Alternative Names

DAB2; Differentially-expressed protein 2; disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein); disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); Disabled-2; DOC2; DOC-2DOC2disabled homolog 2; FLJ26626; mitogen-responsive phosphoprotein

Molecular Weight

Mass (kDA):
82.448 kDA

Genomic Context


Human

Location:	5p13.1
Sequence:	5; NC_000005.10 (39371674..39425233, complement)

Tissue Specificity

Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level).

Subcellular Localizations

Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.