DAAM2 Antibodies

AND DAAM2 ELISA kits, DAAM2 Proteins

Many biological assays use antibodies to detect DAAM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DAAM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DAAM2 antibodies...

We validate the specificity of these antibodies to DAAM2 by testing them on tissues known to express DAAM2 positively and negatively. Browse below to find the DAAM2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DAAM2 Infographic by Boster Bio

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Anti-DAAM2 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A12080
100ul

DAAM2 Overview

Facts about Disheveled-associated activator of morphogenesis 2.

DAAM2 3D structure. Source: alphafold

Disheveled-associated activator of morphogenesis 2 (DAAM2)

Key regulator of the Wnt signaling pathway, which is needed for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Required for canonical Wnt signaling pathway through patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity.

During dorsal patterning of the spinal cord, inhibits oligodendrocytes differentiation via interaction with PIP5K1A. Also regulates non-canonical Wnt signaling pathway.

Gene Information

Human
Gene Name:	DAAM2
Uniprot:	Q86T65
Entrez:	23500

Family

Belongs to:

formin homology family

Alternative Names

dishevelled associated activator of morphogenesis 2

Molecular Weight

Mass (kDA):
123.499 kDA

Genomic Context


Human

Location:	6p21.2
Sequence:	6; NC_000006.12 (39792366..39904877)

Tissue Specificity

Expressed in most tissues examined.

Diseases

Malignant Neoplasms
Neoplasms
Chondrosarcoma
Carcinogenesis
Malignant Neoplasm Of Pancreas
Cell Invasion
Neoplasm Metastasis
Melanoma
Carcinoma
Glioblastoma
Malignant Neoplasm Of Stomach
Malignant Neoplasm Of Breast

Malignant Neoplasm Of Lung
Cholangiocarcinoma
Burkitt Lymphoma
Strabismus
Parathyroid Neoplasms
Kidney Neoplasm
Malignant Neck Neoplasm

Pathways

Convergent Extension
Localization
Gastrulation
Regeneration
Glycosylation
Cell Division
Translation
System Development
Tissue Regeneration
Limb Morphogenesis
Nervous System Development

Cell Differentiation
Central Nervous System Development
Spinal Cord Development
Tissue Homeostasis
Oncogenesis

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DAAM2

References

PMID: 9205841 by Nagase T., et al. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PMID: 17974005 by Bechtel S., et al. The full-ORF clone resource of the German cDNA consortium.