ZFYVE26 Antibodies

AND ZFYVE26 ELISA kits, ZFYVE26 Proteins

Many biological assays use antibodies to detect ZFYVE26, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZFYVE26 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZFYVE26 antibodies...

We validate the specificity of these antibodies to ZFYVE26 by testing them on tissues known to express ZFYVE26 positively and negatively. Browse below to find the ZFYVE26 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: RIMBP2

ZFYVE26 Infographic by Boster Bio

All ZFYVE26 Products

Product

Figures

Specificity

Applications

Price

Anti-SPG15 ZFYVE26 Antibody

Human, Mouse, Rat

ELISA, IF, WB

$449
Cat # A06231
0.1 mg

Anti-ZFY26 ZFYVE26 Antibody

Human

IHC

$380
Cat # A06231-1
100ul

ZFYVE26 Overview

Facts about Zinc finger FYVE domain-containing protein 26.

ZFYVE26 3D structure. Source: alphafold

Zinc finger FYVE domain-containing protein 26 (ZFYVE26)

Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and functions as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

Gene Information

Human
Gene Name:	ZFYVE26
Uniprot:	Q68DK2
Entrez:	23503

Family

Belongs to:

No superfamily

Alternative Names

DKFZp686F19106; DKFZp781H1112; FYVE domain-containing centrosomal protein; FYVE-CENT; KIAA0321zinc finger FYVE domain-containing protein 26; spastic paraplegia 15 (complicated, autosomal recessive); spastizin; SPG15; zinc finger, FYVE domain containing 26

Molecular Weight

Mass (kDA):
284.576 kDA

Genomic Context


Human

Location:	14q24.1
Sequence:	14; NC_000014.9 (67728892..67817293, complement)

Tissue Specificity

Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Localizes to the centrosome during all stages of the cell cycle. Recruited to the midbody during cytokinesis by KIF13A.

Diseases

Spastic Paraplegia, Hereditary
Paraplegia
Spastic Paraplegia
Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Neurodegenerative Disorders
Malignant Neoplasm Of Breast
Impaired Cognition
Optic Atrophy
Cerebellar Diseases

Polyneuropathy
Weakness
Dementia
Paraparesis
Carcinoma

Interacting Proteins

ALAS1
CEP44
GOLGA2
HNRNPC
KRT15

KRT40
KRTAP10-7
KRTAP10-9
MDFI
PNMA1

PNMA5
TADA2A
TDO2
TFIP11
TRAF1

USHBP1

Pathways

Transport
Cytokinesis
Dna Replication
Oxidative Phosphorylation
Abscission
Pathogenesis
Localization

Autophagy
Oncogenesis

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZFYVE26

References

PMID: 18394578 by Hanein S., et al. Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.

PMID: 19084844 by Denora P.S., et al. Spastic paraplegia with thinning of the corpus callosum and white matter abnormalities: further mutations and relative frequency in ZFYVE26/SPG15 in the Italian population.