CXCL12 Antibodies

AND CXCL12 ELISA kits, CXCL12 Proteins

Many biological assays use antibodies to detect CXCL12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CXCL12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CXCL12 antibodies...

We validate the specificity of these antibodies to CXCL12 by testing them on tissues known to express CXCL12 positively and negatively. Browse below to find the CXCL12 antibody that suites your experiment. We have 13 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: SDHD

CXCL12 Infographic by Boster Bio

All CXCL12 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Mouse SDF-1/CXCL12 ELISA Kit PicoKine®

4 Citations 9 Q&As

Mouse

ELISA

$499
Cat # EK0500
96 wells/kit, with removable strips.

Anti-CXCL12 Antibody Picoband®

12 Citations 15 Q&As

Mouse, Rat

IHC, WB

$370
Cat # A00053-1
100 μg/vial

Anti-SDF1 CXCL12 Rabbit Monoclonal Antibody

8 Citations 5 Q&As

Human

IF, ICC, WB

$370
Cat # M00053
100 μl

SDF-1b-Feline Stromal Cell-Derived Factor-1 beta Feline Recombinant Protein (CXCL12)

Feline

$250
Cat # PROTO62657
2ug, 10ug, 1mg

SDF-1b Stromal Cell-Derived Factor-1 beta Rat Recombinant Protein (CXCL12)

Rat

$250
Cat # PROTQ80YV8
2ug, 10ug, 1mg

Mouse CXCL12 Recombinant Protein

Cell Culture

$360
Cat # R00053
5 µg/vial

Anti-CXCL12 Antibody

25 Citations 16 Q&As

Human, Mouse, Rat

ELISA, IF, IHC

$370
Cat # A00053-2
100 μg/vial

Anti-Stromal cell-derived factor 1 CXCL12 Antibody

Human, Mouse

ELISA, ICC, WB

$449
Cat # A00053-3
0.1 mg

Mouse CXCL12/SDF-1 Recombinant Protein

SDS-PAGE

$281
Cat # PROTP40224
Starting from 10ug

Human/Feline CXCL12/SDF-1 alpha Recombinant Protein

SDS-PAGE

$250
Cat # PROTP48061
Starting from 10ug

Human SDF-1/CXCL12 ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK0499
96 wells/kit, with removable strips.

Human recombinant CXCL12 (24-88) (C-X-C motif chemokine 12) protein, AF

Human

Cell Culture

$77
Cat # PROTP48061-8
5ug,20ug,100ug,500ug,1mg

Mouse recombinant CXCL12 (C-X-C motif chemokine 12) protein, AF

Mouse

Cell Culture

$77
Cat # PROTP40224-6
5ug,20ug,100ug,500ug,1mg

CXCL12 Overview

Facts about Stromal cell-derived factor 1.

CXCL12 3D structure. Source: alphafold

Stromal cell-derived factor 1 (CXCL12)

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to cause a rapid and transient rise in the level of intracellular calcium ions and chemotaxis.

Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local websites. Also binds to atypical chemokine receptor ACKR3, which triggers the beta-arrestin pathway and acts as a scavenger receptor for SDF-1.

Gene Information

Human
Gene Name:	CXCL12
Uniprot:	P48061
Entrez:	6387

Family

Belongs to:

intercrine alpha (chemokine CxC) family

Alternative Names

chemokine (C-X-C motif) ligand 12; C-X-C motif chemokine 12; CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; PBSFSDF-1a; Pre-B cell growth-stimulating factor; SCYB12; SDF1; SDF-1; SDF1A; SDF1B; SDF1SDF-1b; stromal cell-derived factor 1; TLSF; TLSF-a; TLSF-b; TPAR1

Molecular Weight

Mass (kDA):
10.666 kDA

Genomic Context


Human

Location:	10q11.21
Sequence:	10; NC_000010.11 (44292088..44385097, complement)

Tissue Specificity

Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

Subcellular Localizations

Secreted.

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Tissue Adhesions
Hiv Infections
Inflammation
Immunologic Deficiency Syndromes
Tumor Angiogenesis
Cell Invasion
Carcinoma
Leukemia
Pathologic Neovascularization

Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Mammary Neoplasms
Neoplasm Invasiveness
Nervousness
Acquired Immunodeficiency Syndrome

Interacting Proteins

CCL11
CCL13
CCL20
CCL21
CCL25

CCL26
CCL28
CCL5
CXCL10
CXCL11

CXCL14
CXCL17
CXCL2
CXCL6
CXCL9

PF4
PF4V1
XCL1
XCL2

Pathways

Chemotaxis
Cell Migration
Angiogenesis
Pathogenesis
Secretion
Cell Adhesion
Cell Proliferation
Localization
Regeneration
Immune Response
Cell Growth
Cell Chemotaxis
Cell Motility

Cell Death
Vasculogenesis
T Cell Migration
Lymphocyte Migration
Wound Healing
Cell Activation
Cell Cycle

PTMs

Phosphorylation
Cleavage
Methylation
Glycosylation
Acetylation
Ubiquitination
Demethylation
Dephosphorylation
Prenylation
Biotinylation

Reduction
Oxidation
Sumoylation
Phosphorothioation
Citrullination
Acylation
Deamidation
Amination
Palmitoylation
Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXCL12

References

PMID: 7490086 by Shirozu M., et al. Structure and chromosomal localization of the human stromal cell- derived factor 1 (SDF1) gene.

PMID: 16626895 by Yu L., et al. Identification and expression of novel isoforms of human stromal cell-derived factor 1.

27 Publications of Boster CXCL12 Antibodies & ELISA Kits

PubMed ID: 10.3892/mmr.2014.2302, Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expres...
PubMed ID: 10.3892/etm.2016.3248, Treatment of radiation‑induced acute intestinal injury with bone marrow‑deri...
PubMed ID: 10.3748/wjg.v17.i19.2389, CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma
PubMed ID: 10.3748/wjg.v13.i28.3886, Selective tropism of liver stem cells to hepatocellular carcinoma in vivo
PubMed ID: 10.3390/ijms18112265, Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence...
PubMed ID: 10.1269/jrr.0531, Crucial Role of SDF-1/CXCR4 Interaction in the Recruitment of Transplanted Derma...
PubMed ID: 10.1186/1756-9966-27-62, Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineura...
PubMed ID: 10.1038/s41598-017-01938-3, Matrix elasticity-modified scaffold loaded with SDF-1α improves the in situ reg...
PubMed ID: 10.1016/j.mvr.2008.10.003, Estrogen-replacement therapy promotes angiogenesis after acute myocardial infarc...
PubMed ID: 10.1016/j.lfs.2017.05.001, Role of SDF-1/CXCR4 and cytokines in the development of ovary injury in chemothe...
PubMed ID: 10.1016/j.brainres.2007.11.068, SDF-1α/CXCR4-mediated migration of systemically transplanted bone marrow stroma...
PubMed ID: 10.1007/s12185-009-0488-x, Interaction of SDF-1α and CXCR4 plays an important role in pulmonary cellular i...
PubMed ID: 10.1007/s10637-010-9578-0, Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin i...
PubMed ID: 33344233, He K,Liu S,Xia Y,Xu J,Liu F,Xiao J,Li Y,Ding Q,Lu L,Xiang G,Zhan M.CXCL12 and IL...
PubMed ID: 28490814, Matrix elasticity-modified scaffold loaded with SDF-1%u03B1 improves the in situ...
PubMed ID: 25087604, Effect of Ermiao Recipe (%u4E8C%u5999%u65B9) with medicinal guide Angelicae P...
PubMed ID: 29143796, Angelica sinensis Polysaccharides Ameliorate Stress-Induced Premature Senescence...
PubMed ID: 27907131, iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human D...
PubMed ID: 18983683, Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineura...
PubMed ID: 27284330, Treatment of radiation-induced acute intestinal injury with bone marrow-derived ...
PubMed ID: 24912495, Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF-1? expressio...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page