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Src substrate cortactin Antibodies
AND CTTN ELISA kits, Src substrate cortactin Proteins
Many biological assays use antibodies to detect Src substrate cortactin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Src substrate cortactin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Src substrate cortactin antibodies...
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CTTN Infographic by Boster Bio
All CTTN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01253
100 μl
Cat # M01253
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01253-1
100 μg/vial
Cat # A01253-1
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1135
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1135
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2379
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2379
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2380
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2380
1 kit, containing two 96-well plates and all necessary reagents
CTTN Overview
Facts about Src substrate cortactin.
Src substrate cortactin (CTTN)
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration.
Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | CTTN |
| Uniprot: | Q14247 |
| Entrez: | 2017 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
1110020L01Rik; Amplaxin; Cortactin; CTTN; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 srcsubstrate); EMS1; EMS1amplaxin; FLJ34459; Oncogene EMS1; src substrate cortactin
Molecular Weight
Mass (kDA):
61.586 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (70398506..70436584) |
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite. Cell projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Cell junction. Cell junction, focal adhesion. Membrane, clathrin-coated pit. Cell projection, dendritic spine. Cytoplasm, cell cortex. Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the c
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Tissue Adhesions
- Neoplasm Metastasis
- Cell Invasion
- Malignant Squamous Cell Neoplasm
- Mammary Neoplasms
- Neoplasm Invasiveness
- Malignant Neoplasm Of Breast
- Metastatic Malignant Neoplasm To The Lymph Node
- Head And Neck Carcinoma
- Cell Transformation, Neoplastic
Interacting Proteins
- ARRB2
- ASAP1
- Cbll1
- DNM2
- EGFR
- HDAC6
- Kcnma1
- PTPN1
- WAS
Pathways
- Localization
- Cell Migration
- Cell Motility
- Endocytosis
- Cell Proliferation
- Cell Adhesion
- Cell Cycle
- Secretion
- Rna Interference
- Actin Nucleation
- Dna Amplification
- Pathogenesis
- Platelet Activation
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Dephosphorylation
- Biotinylation
Research Areas
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTTN
bosterbio.com/bosterbio-gene-info-cards/CTTN
References
PMID: 1532244 by Schuuring E.M.D., et al. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.
PMID: 8474448 by Schuuring E.M.D., et al. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell- substratum contact sites.