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- Table of Contents
Facts about Cilia- and flagella-associated protein 298.
Required for proper positioning of the cilium in the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity).
Human | |
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Gene Name: | CFAP298 |
Uniprot: | P57076 |
Entrez: | 56683 |
Belongs to: |
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CFAP298 family |
C21orf48; chromosome 21 open reading frame 48; chromosome 21 open reading frame 59; FLJ20467; FLJ37137; FLJ40247; hypothetical protein LOC56683; kur; kurly
Mass (kDA):
33.224 kDA
Human | |
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Location: | 21q22.11 |
Sequence: | 21; NC_000021.9 (32599354..32612871, complement) |
Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Partially colocalized with SASS6 in cytoplasmic puncta, suggesting a centrosomal localization.
PMID: 24094744 by Austin-Tse C., et al. Zebrafish ciliopathy screen plus human mutational analysis identifies C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia.
PMID: 29601588 by Cho K.J., et al. ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.