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- Table of Contents
Facts about Protein KASH5.
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the Link between the nuclear lamina and the cytoskeleton.
The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes.
Mouse | |
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Gene Name: | Ccdc155 |
Uniprot: | Q80VJ8 |
Entrez: | 384619 |
Belongs to: |
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No superfamily |
coiled-coil domain containing 155; coiled-coil domain-containing protein 155; DKFZp434A2223; FLJ32658
Mass (kDA):
72.444 kDA
Mouse | |
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Location: | 7|7 B3 |
Sequence: | 7; |
Restricted to the testis and the early ootidogenesis ovary. Expressed in spermatocytes and oocytes (at protein level).
PMID: 22826121 by Morimoto A., et al. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
PMID: 24062341 by Horn H.F., et al. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton.