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CBX7 Antibodies
AND CBX7 ELISA kits, CBX7 Proteins
Many biological assays use antibodies to detect CBX7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBX7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBX7 antibodies...
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CBX7 Infographic by Boster Bio
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CBX7 Overview
Facts about Chromobox protein homolog 7.
Chromobox protein homolog 7 (CBX7)
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, during development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility.
Promotes histone H3 trimethylation in'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and maybe also other proteins.
Gene Information
| Human | |
|---|---|
| Gene Name: | CBX7 |
| Uniprot: | O95931 |
| Entrez: | 23492 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
chromobox homolog 7; chromobox protein homolog 7
Molecular Weight
Mass (kDA):
28.341 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (39130772..39152680, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Carcinogenesis
- Adenoma
- Stomach Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Stomach
- Adenocarcinoma
- Tumor Progression
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
Interacting Proteins
- BMI1
- MOV10
- PCGF1
- PCGF2
- PCGF3
- PCGF6
- RING1
- RNF2
Pathways
- Senescence
- Cell Growth
- Gene Silencing
- Cellular Homeostasis
- Cell Cycle
- Localization
- Methylation
- Cellular Senescence
- Oncogenesis
- Cell Proliferation
- Pathogenesis
- Cell Migration
- Dna Hypermethylation
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBX7
bosterbio.com/bosterbio-gene-info-cards/CBX7
References
PMID: 14647293 by Gil J., et al. Polycomb CBX7 has a unifying role in cellular lifespan.
PMID: 19791798 by Bezsonova I., et al. Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.