CBX4 Antibodies

AND CBX4 ELISA kits, CBX4 Proteins

Many biological assays use antibodies to detect CBX4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBX4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBX4 antibodies...

We validate the specificity of these antibodies to CBX4 by testing them on tissues known to express CBX4 positively and negatively. Browse below to find the CBX4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CBX4 Infographic by Boster Bio

All CBX4 Products

Product

Figures

Specificity

Applications

Price

Anti-PC2 CBX4 Antibody

7 Q&As

Human

ELISA, IF, WB

$599
Cat # A03388-1
100ug

Anti-E3 SUMO-protein ligase CBX4 CBX4 Antibody

Human, Mouse, Rat

ELISA, IF, WB

$449
Cat # A03388
0.1 mg

Anti-CBX4 Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M03388
100 μl/vial

CBX4 Overview

Facts about E3 SUMO-protein ligase CBX4.

CBX4 3D structure. Source: alphafold

E3 SUMO-protein ligase CBX4 (CBX4)

E3 SUMO-protein ligase which eases SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation leading to p21/CDKN1A expression.

Monosumoylates ZNF131 (PubMed:22825850). .

Gene Information

Human
Gene Name:	CBX4
Uniprot:	O00257
Entrez:	8535

Family

Belongs to:

No superfamily

Alternative Names

chromobox homolog 4 (Drosophila Pc class); chromobox homolog 4; Chromobox protein homolog 4; Drosophila); E3 SUMO-protein ligase CBX4; hPC2; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; Polycomb 2 homolog

Molecular Weight

Mass (kDA):
61.368 kDA

Genomic Context


Human

Location:	17q25.3
Sequence:	17; NC_000017.11 (79833156..79839440, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Nucleus speckle. Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235).

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Osteosarcoma
Malignant Neoplasm Of Prostate
Malignant Paraganglionic Neoplasm
Prostatic Neoplasms
Metaplastic Cell Transformation
Hyperhomocysteinemia
Malignant Neoplasm Of Breast
Tumor Progression
Bone Neoplasms

Parkinson Disease
Lymphoma
Mammary Neoplasms
Mammary Neoplasms, Experimental
Adenocarcinoma
Neoplasm Recurrence, Local
Severe Acute Respiratory Syndrome

Interacting Proteins

BMI1
CBX8
CSNK2A1
CSNK2B
CTBP1

HIF1A
PCGF6
RNF2
SUMO1
YWHAB

YWHAE
YWHAZ

Pathways

Localization
Gene Silencing
Conjugation
Mitosis
Methylation
Stem Cell Differentiation
Cell Cycle
Cell Differentiation
Interphase
Cell Proliferation
Cell Growth
Histone H3-k9 Methylation
Cell Activation

Cellular Homeostasis
Cell Division
Stem Cell Proliferation
Segmentation
Histone Deacetylation
Transsulfuration
G1 Phase

PTMs

Sumoylation
Methylation
Phosphorylation

Demethylation
Deacetylation
Dephosphorylation

Ubiquitination

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBX4

References

PMID: 9315667 by Satijn D.P.E., et al. Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.

PMID: 19266028 by Salichs E., et al. Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment.