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CAMK1 Antibodies
AND CAMK1 ELISA kits, CAMK1 Proteins
Many biological assays use antibodies to detect CAMK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CAMK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CAMK1 antibodies...
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CAMK1 Infographic by Boster Bio
All CAMK1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, ICC, WB
$335
Cat # P02576
100ul
Cat # P02576
100ul
Human, Mouse, Rat
ELISA
$480
Cat # EKC1077
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1077
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2222
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2222
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A02576T177
100ul
Cat # A02576T177
100ul
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02576
100 μl/vial
Cat # M02576
100 μl/vial
CAMK1 Overview
Facts about Calcium/calmodulin-dependent protein kinase type 1.
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Calcium/calmodulin-dependent protein kinase that operates from the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, modulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for complete long-term potentiation (LTP) and ERK2-dependent translational activation.
Downstream of NMDA receptors, promotes the creation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on'Ser- 694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'.
Gene Information
| Human | |
|---|---|
| Gene Name: | CAMK1 |
| Uniprot: | Q14012 |
| Entrez: | 8536 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
calcium/calmodulin-dependent protein kinase I; calcium/calmodulin-dependent protein kinase type 1; CaM kinase I alpha; CaM Kinase I; CAMKI; caM-KI; caMKI-alpha; EC 2.7.11; EC 2.7.11.17; MGC120317; MGC120318
Molecular Weight
Mass (kDA):
41.337 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p25.3 |
| Sequence: | 3; NC_000003.12 (9757345..9769987, complement) |
Tissue Specificity
Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.
Subcellular Localizations
Cytoplasm. Nucleus. Predominantly cytoplasmic.
Diseases
- Nervousness
- Neoplasms
- Hypertrophy
- Cardiac Hypertrophy
- Malignant Neoplasms
- Mammary Neoplasms
- Hypertensive Disease
- Adenoma
- Carcinoma
- Globus Hystericus
- Pheochromocytoma
- Lymphoma
- Diabetes Mellitus
Pathways
- Localization
- Secretion
- Transport
- Nuclear Export
- Cell Proliferation
- Protein Phosphorylation
- Brain Development
- Inflammatory Response
- Cholesterol Transport
- Nuclear Import
- Cell Death
- Regulation Of Protein Phosphorylation
- Osteoclast Differentiation
PTMs
- Phosphorylation
- Dephosphorylation
- Sumoylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAMK1
bosterbio.com/bosterbio-gene-info-cards/CAMK1
References
PMID: 7641687 by Haribabu B., et al. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.
PMID: 9662074 by Hsu L.-S., et al. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.