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- Table of Contents
Facts about E3 ubiquitin-protein ligase CBL-C.
Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation.
Human | |
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Gene Name: | CBLC |
Uniprot: | Q9ULV8 |
Entrez: | 23624 |
Belongs to: |
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No superfamily |
Cas-Br-M (murine) ecotropic retroviral transforming sequence c; Cas-Br-M (murine) ectropic retroviral transforming sequence c; CBL3; CBL-3; CBL-SL; RING finger protein 57; RNF57SH3-binding protein CBL-3; SH3-binding protein CBL-C; signal transduction protein CBL-C
Mass (kDA):
52.456 kDA
Human | |
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Location: | 19q13.32 |
Sequence: | 19; NC_000019.10 (44777855..44800652) |
Ubiquitous.
PMID: 10571044 by Kim M., et al. Molecular cloning and characterization of a novel cbl-family gene, cbl-c.
PMID: 10362357 by Keane M.M., et al. cbl-3: a new mammalian cbl family protein.