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Calsequestrin-1 Antibodies
AND CASQ1 ELISA kits, Calsequestrin-1 Proteins
Many biological assays use antibodies to detect Calsequestrin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Calsequestrin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Calsequestrin-1 antibodies...
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CASQ1 Infographic by Boster Bio
All CASQ1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M05235
100 μl
Cat # M05235
100 μl
CASQ1 Overview
Facts about Calsequestrin-1.
Calsequestrin-1 (CASQ1)
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and so acts as an internal calcium store in muscle (PubMed:28895244). Calcium ions are bound by clusters of acidic residues in the protein surface, often at the interface between subunits.
Can bind around 80 Ca(2+) ions (PubMed:28895244). Regulates the discharge of lumenal Ca(2+) through the calcium release channel RYR1; this plays an significant role in triggering muscle contraction.
Gene Information
| Human | |
|---|---|
| Gene Name: | CASQ1 |
| Uniprot: | P31415 |
| Entrez: | 844 |
Family
| Belongs to: |
|---|
| calsequestrin family |
Alternative Names
calmitin; calmitine; calsequestrin 1 (fast-twitch, skeletal muscle); Calsequestrin, skeletal muscle isoform; calsequestrin-1; CASQ; PDIB1
Molecular Weight
Mass (kDA):
45.16 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.2 |
| Sequence: | 1; NC_000001.11 (160190575..160201886) |
Tissue Specificity
Expressed in myoblasts (at protein level).
Subcellular Localizations
Endoplasmic reticulum. Sarcoplasmic reticulum. Sarcoplasmic reticulum lumen. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Mitochondrion matrix. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells (PubMed:28895244). In a minority of cells, homogeneously detected in the ER lumen (PubMed:28895244). Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellula
Diseases
- Myopathy
- Dystrophy
- Muscular Dystrophy
- Malignant Hyperpyrexia Due To Anesthesia
- Malignant Paraganglionic Neoplasm
- Graves Disease
- Thyroiditis
- Muscular Dystrophy, Animal
- Hashimoto Disease
- Autoimmunity
- Malignant Neoplasms
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
Pathways
- Pathogenesis
- Regeneration
- Glycosylation
- Muscle Contraction
- Localization
- Transport
- Membrane Depolarization
- Sensitization
- Larval Development
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASQ1
bosterbio.com/bosterbio-gene-info-cards/CASQ1
References
PMID: 2321095 by Fujii J., et al. Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene.
PMID: 7945294 by Bataille N., et al. Molecular cloning of human calmitine, a mitochondrial calcium binding protein, reveals identity with calsequestrine.