CACNG2 Antibodies

AND CACNG2 ELISA kits, CACNG2 Proteins

Many biological assays use antibodies to detect CACNG2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CACNG2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CACNG2 antibodies...

We validate the specificity of these antibodies to CACNG2 by testing them on tissues known to express CACNG2 positively and negatively. Browse below to find the CACNG2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CACNG2 Infographic by Boster Bio

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CACNG2 (NM_006078) Human Over-expression Lysate

Human

$628
Cat # LS010369
100 µg

CACNG2 Overview

Facts about Voltage-dependent calcium channel gamma-2 subunit.

CACNG2 3D structure. Source: alphafold

Voltage-dependent calcium channel gamma-2 subunit (CACNG2)

Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their degrees of activation, deactivation and desensitization.

Does not reveal subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

Gene Information

Human
Gene Name:	CACNG2
Uniprot:	Q9Y698
Entrez:	10369

Family

Belongs to:

PMP-22/EMP/MP20 family

Alternative Names

calcium channel, voltage-dependent, gamma subunit 2; FLJ41437; MGC138502; MGC138504; Neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; voltage-dependent calcium channel gamma-2 subunit

Molecular Weight

Mass (kDA):
35.966 kDA

Genomic Context


Human

Location:	22q12.3
Sequence:	22; NC_000022.11 (36560869..36702858, complement)

Tissue Specificity

Brain.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Diseases

Epilepsy
Absence Epilepsy
Ataxia
Cerebellar Ataxia
Schizophrenia
Nervousness
Depressive Disorder
Bipolar Disorder
Gait Ataxia
Malnutrition
Pain

Nervous System Disorder
Neuralgia
Chronic Pain
Lethargy
Trinucleotide Repeat Expansion
Single Gene Defect

Pathways

Synaptic Transmission
Localization
Transport
Pathogenesis
Endocytosis
Cell Adhesion
Synapse Maturation
Protein Phosphorylation
Intracellular Transport
Proteolysis
Vesicle Docking
Response To Pain
Reflex

Endoplasmic Reticulum Unfolded Protein Response
Swimming
Membrane Depolarization
Sensitization
Receptor Internalization
Cellular Localization
Cell Death

PTMs

Phosphorylation
Dephosphorylation

Palmitoylation
Nitrosylation

Depalmitoylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CACNG2

References

PMID: 10221464 by Black J.L. III, et al. Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications.

PMID: 20805473 by Shi Y., et al. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.