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CITED2 Antibodies
AND CITED2 ELISA kits, CITED2 Proteins
Many biological assays use antibodies to detect CITED2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CITED2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CITED2 antibodies...
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CITED2 Overview
Facts about Cbp/p300-interacting transactivator 2.
Cbp/p300-interacting transactivator 2 (CITED2)
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation.
Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | CITED2 |
| Uniprot: | Q99967 |
| Entrez: | 10370 |
Family
| Belongs to: |
|---|
| CITED family |
Alternative Names
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain2,cbp/p300-interacting transactivator 2; Cited2; Cited-2; MRG-1; MRG1melanocyte-specific gene 1-related gene 1; MSG1-related gene 1; MSG-related protein 1; P35srj
Molecular Weight
Mass (kDA):
28.497 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q24.1 |
| Sequence: | 6; NC_000006.12 (139371807..139374648, complement) |
Subcellular Localizations
Nucleus. Colocalizes with EP300 in dot-like structures.
Diseases
- Hypoxia
- Neoplasms
- Malignant Neoplasms
- Congenital Heart Defects
- Tumor Angiogenesis
- Congenital Absence
- Carcinoma
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Congenital Heart Disease
- Ventricular Septal Defects
- Mammary Neoplasms
- Heart Diseases
Interacting Proteins
- EP300
- HNF4A
- TFAP2C
Pathways
- Cell Cycle
- Angiogenesis
- Localization
- Response To Hypoxia
- Cell Death
- Cell Growth
- Cell Proliferation
- Tube Development
- Heart Development
- Neural Tube Development
- Pathogenesis
- Cell Adhesion
- Sex Determination
PTMs
- Acetylation
- Phosphorylation
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CITED2
bosterbio.com/bosterbio-gene-info-cards/CITED2
References
PMID: 8901575 by Shioda T., et al. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation.
PMID: 10552932 by Leung M.K., et al. Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1.