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- Table of Contents
Facts about Cytohesin-3.
Promotes guanine-nucleotide exchange on ARF1 and ARF6.
Promotes the activation of ARF factors through replacement of GDP with GTP.Play a role in the epithelial polarization (By similarity). .
Human | |
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Gene Name: | CYTH3 |
Uniprot: | O43739 |
Entrez: | 9265 |
Belongs to: |
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No superfamily |
ARF nucleotide-binding site opener 3; ARNO3PH, SEC7 and coiled-coil domain-containing protein 3; cytohesin 3; General receptor of phosphoinositides 1; Grp1; GRP1cytohesin-3; pleckstrin homology, Sec7 and coiled-coil domains 3; Protein ARNO3; PSCD3pleckstrin homology, Sec7 and coiled/coil domains 3
Mass (kDA):
46.349 kDA
Human | |
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Location: | 7p22.1 |
Sequence: | 7; NC_000007.14 (6161779..6272624, complement) |
Almost absent from liver, thymus and peripheral blood lymphocytes.
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, tight junction. Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
PMID: 9707577 by Franco M., et al. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function.
PMID: 10652308 by Ogasawara M., et al. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.