Cytochrome P450 4F8 (CYP4F8)

Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows very little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4.

Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6).