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- Table of Contents
Facts about Cytochrome P450 4F8.
Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6).
Human | |
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Gene Name: | CYP4F8 |
Uniprot: | P98187 |
Entrez: | 11283 |
Belongs to: |
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cytochrome P450 family |
cytochrome P450 4F8; CPF8; CYPIVF8; cytochrome P450, family 4, subfamily F, polypeptide 8
Mass (kDA):
59.995 kDA
Human | |
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Location: | 19p13.12 |
Sequence: | 19; NC_000019.10 (15615207..15630639) |
Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions.
Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
PMID: 10405341 by Bylund J., et al. Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles.
PMID: 10791960 by Bylund J., et al. Identification of CYP4F8 in human seminal vesicles as a prominent 19- hydroxylase of prostaglandin endoperoxides.