PNKP Antibodies

AND PNKP ELISA kits, PNKP Proteins

Many biological assays use antibodies to detect PNKP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PNKP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PNKP antibodies...

We validate the specificity of these antibodies to PNKP by testing them on tissues known to express PNKP positively and negatively. Browse below to find the PNKP antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PNKP Infographic by Boster Bio

All PNKP Products

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Product

Figures

Specificity

Applications

Price

Anti-PNK PNKP Antibody

5 Q&As

Human, Chimpanzee

ELISA, WB

$629
Cat # A03566
100ug

Anti-PNKP Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A03566-1
100ul

PNK (PNKP) (NM_007254) Human Recombinant Protein

$813
Cat # PROTQ96T60
20 µg

Anti-PNK / PNKP Rabbit Monoclonal Antibody

Human

IF, IHC, ICC, WB

$370
Cat # M03566
100 μl/vial

Anti-PNK / PNKP Rabbit Monoclonal Antibody

Human

IP, IHC, WB

$370
Cat # M03566-1
100 μl/vial

PNK (PNKP) (NM_007254) Human Over-expression Lysate

Human

$628
Cat # LS011284
100 µg

PNKP Overview

Facts about Bifunctional polynucleotide phosphatase/kinase.

PNKP 3D structure. Source: alphafold

Bifunctional polynucleotide phosphatase/kinase (PNKP)

Plays a vital role in the repair of DNA damage, working as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone.

Gene Information

Human
Gene Name:	PNKP
Uniprot:	Q96T60
Entrez:	11284

Family

Belongs to:

No superfamily

Alternative Names

DNA 5'-kinase/3'-phosphatase; EIEE10; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); MCSZ; PNKbifunctional polynucleotide phosphatase/kinase; polynucleotide kinase 3'-phosphatase; Polynucleotide kinase-3'-phosphatase

Molecular Weight

Mass (kDA):
57.076 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (49861204..49867576, complement)

Tissue Specificity

Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Ataxia Telangiectasia
Malignant Neoplasm Of Lung
Lung Neoplasms
Microcephaly
Developmental Delay (disorder)
Nervous System Disorder
Developmental Disabilities
Heredodegenerative Disorders, Nervous System
Adenoma
Early Infantile Epileptic Encephalopathy With Burst-suppression

Polyps
Ataxia
Malignant Tumor Of Colon
Carcinoma
Immunologic Deficiency Syndromes
Oculomotor Apraxia
Lymphoma

Interacting Proteins

FOXO3
IKZF1
TNIP1
TRIM37
XRCC1

XRCC4
ZBTB14
ZNF639

Pathways

Dna Repair
Rna Repair
Hypersensitivity
Double-strand Break Repair
Cell Killing
Aging
Dna Replication
Translation
Single Strand Break Repair
Dna Alkylation
Induction Of Apoptosis
Localization

Methylation
Mitochondrial Dna Repair
Regulation Of Dna Repair
Cell Growth
Response To Radiation
Pathogenesis
Rna Interference

PTMs

Phosphorylation
Cleavage

Dephosphorylation
Methylation

Research Areas

DNA Repair
Protein Phosphatase
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNKP

References

PMID: 10446192 by Jilani A., et al. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage.

PMID: 10446193 by Karimi-Busheri F., et al. Molecular characterization of a human DNA kinase.