Cytochrome P450 2A6 Antibodies

Cytochrome P450 2A6 (CYP2A6)

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.

Competent in the metabolic activation of aflatoxin B1. Constitutes the significant nicotine C-oxidase.

Gene Information

Human
Gene Name:	CYP2A6
Uniprot:	P11509
Entrez:	1548

Family

Belongs to:
cytochrome P450 family

Alternative Names

Coumarin 7-hydroxylase; CPA6; CYP2A3P450C2A; CYP2AEC 1.14.14.1; CYPIIA6; cytochrome P450 2A6; Cytochrome P450 IIA3; Cytochrome P450(I); cytochrome P450, family 2, subfamily A, polypeptide 6; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6; flavoprotein-linked monooxygenase; P450PB; xenobiotic monooxygenase

Molecular Weight

Mass (kDA):
56.517 kDA

Genomic Context

Human
Location:	19q13.2
Sequence:	19; NC_000019.10 (40843541..40850447, complement)

Tissue Specificity

Liver.

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Lung
• Neoplasms
• Lung Neoplasms
• Carcinoma
• Tobacco Use Disorder
• Nicotine Dependence
• Liver Carcinoma
• Hepatitis
• Adenocarcinoma
• Malignant Squamous Cell Neoplasm
• Salmonella Infections
• Tobacco Dependence Syndrome

• Esophageal Neoplasms
• Liver Diseases
• Carcinogenesis
• Cell Transformation, Neoplastic
• Stomach Neoplasms
• Malignant Neoplasm Of Breast
• Liver Neoplasms

Pathways

• Excretion
• Conjugation
• Gene Conversion
• Pathogenesis
• Demethylation
• Dna Repair
• Translation
• Localization
• Secretion
• Transport
• Cell Cycle
• Methylation
• Cell Death

• Sulfation
• Oxidative Demethylation
• Reverse Transcription
• Mrna Stabilization
• Response To Nicotine
• Insulin Secretion
• Viral Replication

PTMs

• Hydroxylation
• Oxidation
• Demethylation
• Reduction
• Cleavage

• Phosphorylation
• Sulphation
• Acetylation
• Methylation
• Nitration

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2A6

Best Uses Of The CYP2A6 Marker

You've come to the right place if you are looking for a high-quality CYP2A6 marking device. Here, you will learn about the many applications for the marker CYP2A6. The results can be used to submit species, applications, and special samples. The results can be submitted for species, applications, and other samples. You can also get credit for products. These benefits are available to scientists all over the world. These benefits can be applied to all types of research.

The CYP2A6 marker can be used as a CYP2D6 marker

Studies on pharmacokinetics have revealed that some people have higher drug clearance when they possess a CYP2A6 and CYP2D6 marker. CYP2D6 can be a common marker and a patient's genetic profile could have an impact on the pharmacokinetics of the drug. The precise significance of this association is not known. Different plasma concentrations of different drugs are associated with CYP2A6 or CYP2D6 genotypes.

Although there are numerous studies linking the CYP2A6 gene to smoking habits, very few studies have shown that CYP2A6 activity can be linked with successful nicotine cessation. In addition, a study by Mwenifumbo et al. showed that CYP2A6 genotypes are associated with a reduced risk of developing lung cancer in African American smokers.

A study of Kinh people found that the frequency of the CYP2D6*4 genetic variant was significantly lower than other Asian populations. The same was true for the gene in American or European populations. The Kinh population had a higher percentage of the CYP2A6*5 variant than the other Asian countries. This was contrary to the similarity found in Japan and Korea.

The brain's role in CYP2D6 is not completely understood. It is also not clear if it influences serotonergic and dopaminergic neurotransmission. However, it could affect the hypothesis of sustained attention which suggests that reward enhances the performance of attention. Dopamine is also activated when there is a reward in the environment. It also activates during sustained attention and reactivity to tasks that reward.

While there isn't a statistically significant connection between the CYP2A6 gene copy number and their risk of developing HCC, it is still important to be aware of this connection for patients with an ancestral history of the disease. A patient's CYP2A6 gene copy number could be a biomarker for bladder cancer treatment. Its over-expression may help predict the likelihood of developing the disease.

Furthermore, CYP2D6 genetic variation could affect the activity CYP2D6 enzymes. Individuals who have CYP2D6 genetic variations could be affected by drug reactions that are distinct. The CYP2D6 genome study aims to determine all variants of the CYP2D6 genes and also to determine their genotype frequency. Multiplex ligand dependent probe amplification and Sanger sequencing are employed to identify variants.

A study based on a putative CYP2A6 sequence and the CYP2A6 mark in chickens has revealed an the cytochrome P450 2-like polymorphism in broilers from AA. The AA broiler CYP2A6 gene was identified through degenerate primers. The NCBI sequenced PCR products. The alignment of the sequences showed that the nucleotide sequence was very similar to human CYP2A6.

Cyps are a family of enzymes that catalyze the metabolization of a variety of substances, including drugs and endogenous substrates. The CYP2A6 variants of people could affect the way they process drugs. Genetic polymorphisms in CYPs are associated with diseases and disorders. Although it isn't feasible to diagnose a condition however, it is possible to determine if a patient is at risk of being affected by an medication based on their character.

The P450 CYP2A6, which is the main one in the human body, catalyzes nicotine and cotinine. Studies have revealed that high levels of CYP2A6 are associated with liver cancer as well as chronic inflammation. The enzyme's activity within microsomes of the liver quail that activates AFB1 in AFBO. There are many other instances of CYP2A6 gene transcription in humans.

Curcumin reduces CYP2A6 enzyme activity. The results of this study showed that a dose-dependent effect of curcumin on the activity of the enzyme CYP2A6 was observed. The amount of curcumin consumed by AFB1-fed mice affected the activity of CYP2A6 in a dose-dependent way. Curcumin significantly inhibits CYP2A6 activity. This study highlights the importance curcumin is in the treatment of various diseases.