Cystinosin Antibodies

AND CTNS ELISA kits, Cystinosin Proteins

Many biological assays use antibodies to detect Cystinosin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cystinosin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cystinosin antibodies...

We validate the specificity of these antibodies to Cystinosin by testing them on tissues known to express CTNS positively and negatively. Browse below to find the CTNS antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CTNS Infographic by Boster Bio

All CTNS Products

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Product

Figures

Specificity

Applications

Price

Anti-Cystinosin CTNS Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A01452
100ul

CTNS (NM_004937) Human Recombinant Protein

$813
Cat # PROTO60931
20 µg

CTNS (NM_001031681) Human Over-expression Lysate

Human

$628
Cat # LS001497
100 µg

CTNS Overview

Facts about Cystinosin.

CTNS 3D structure. Source: alphafold

Cystinosin (CTNS)

Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.

Gene Information

Human
Gene Name:	CTNS
Uniprot:	O60931
Entrez:	1497

Family

Belongs to:

cystinosin family

Alternative Names

CTNS-LSB; cystinosin; cystinosis, nephropathic; PQLC4

Molecular Weight

Mass (kDA):
41.738 kDA

Genomic Context


Human

Location:	17p13.2
Sequence:	17; NC_000017.11 (3636468..3663103)

Tissue Specificity

Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes. Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions.

Subcellular Localizations

[Isoform 1]: Lysosome membrane; Multi-pass membrane protein. Melanosome.; [Isoform 2]: Lysosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Cystinosis
Fanconi Syndrome
Kidney Diseases
Kidney Failure
Lysosomal Storage Diseases
Storage Disease
Kidney Failure, Chronic
Corneal Diseases
Photophobia
Juvenile Nephropathic Cystinosis (disorder)
Myopathy
Hypothyroidism

Diabetes Mellitus
Proteinuria Of Undiagnosed Cause
Growth Retardation
Rickets
Cataract
Disorder Of Eye
Senile Cataract

Pathways

Transport
Pathogenesis
Lysosomal Transport
Localization
Oxidative Phosphorylation
Muscle Atrophy
Hyphal Growth
Brain Development
Aging
Proteolysis
Immune Response
Pigmentation
Amino Acid Homeostasis

Autolysis
Virulence
Translation
Antigen Processing And Presentation
Cell Death
Cognition
Vacuolar Acidification

PTMs

Phosphorylation
Reduction

Glycosylation
Oxidation

Research Areas

Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTNS

References

PMID: 9537412 by Town M., et al. A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis.

PMID: 10673275 by Touchman J.W., et al. The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.