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Catenin beta-1 Antibodies
AND CTNNB1 ELISA kits, Catenin beta-1 Proteins
Many biological assays use antibodies to detect Catenin beta-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Catenin beta-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Catenin beta-1 antibodies...
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CTNNB1 Infographic by Boster Bio
All CTNNB1 Products
Product
Figures
Specificity
Applications
Price
Anti-beta Catenin/CTNNB1 Antibody Picoband®
23 Citations
Human, Mouse, Rat
IF, IHC, IHC-F, ICC, WB
$370
Cat # PA1212
100 μg/vial
Cat # PA1212
100 μg/vial
Anti-beta Catenin/CTNNB1 Antibody Picoband®
20 Citations 1 Q&As
Human, Mouse, Rat
IHC, ICC, WB
$370
Cat # PA1212-1
100 μg/vial
Cat # PA1212-1
100 μg/vial
Anti-Catenin, beta (p120) CTNNB1 Monoclonal Antibody
13 Citations
Chicken, Cow, Dog, Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$486
Cat # M00004
100ug/vial
Cat # M00004
100ug/vial
Anti-beta Catenin/CTNNB1 Antibody Picoband®
6 Citations 7 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00004
100 μg/vial
Cat # A00004
100 μg/vial
Human, Rat
WB
$370
Cat # P00004
100 μl
Cat # P00004
100 μl
Anti-beta Catenin CTNNB1 Rabbit Monoclonal Antibody
14 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00004-1
100 μl
Cat # M00004-1
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00004-2
100 μg/vial
Cat # M00004-2
100 μg/vial
Human
IHC, WB
$431
Cat # M00004-3
100uL
Cat # M00004-3
100uL
Catenin-beta Colorimetric Cell-Based ELISA Kit
1 Citations
Human, Mouse, Rat
ELISA
$480
Cat # EKC1091
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1091
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2228
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2228
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2360
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2360
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2361
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2361
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2542
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2542
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
IHC
$482
Cat # A00004S33S37T41
100ul
Cat # A00004S33S37T41
100ul
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$380
Cat # A00004S37
100ul
Cat # A00004S37
100ul
Human, Mouse, Rat
ELISA, WB
$380
Cat # A00004T41S45-1
100ul
Cat # A00004T41S45-1
100ul
Human, Mouse, Rat
ELISA, IHC-P, WB
$380
Cat # A00004Y654
100ul
Cat # A00004Y654
100ul
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00004Y489
100ul
Cat # A00004Y489
100ul
Human, Mouse, Rat
WB
$370
Cat # M00004T41S45
100 µl/vial
Cat # M00004T41S45
100 µl/vial
CTNNB1 Overview
Facts about Catenin beta-1.
Catenin beta-1 (CTNNB1)
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 through BTRC and its subsequent degradation by the proteasome.
In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it functions as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E- cadherin:catenin adhesion complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | CTNNB1 |
| Uniprot: | P35222 |
| Entrez: | 1499 |
Family
| Belongs to: |
|---|
| beta-catenin family |
Alternative Names
bCatenin; beta 1 (88kD); beta-Catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; CTNNB1; DKFZp686D02253; FLJ25606; FLJ37923
Molecular Weight
Mass (kDA):
85.497 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p22.1 |
| Sequence: | 3; NC_000003.12 (41199422..41240445) |
Tissue Specificity
Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse. Cytoplasm, cytoskeleton, cilium basal body. Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Adenomatous Polyposis Coli
- Polyposis
- Neoplasm Metastasis
- Colorectal Cancer
- Colorectal Neoplasms
- Adenocarcinoma
- Carcinogenesis
- Malignant Tumor Of Colon
Pathways
- Localization
- Cell Adhesion
- Cell-cell Adhesion
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Cycle
- Methylation
- Cell Migration
- Cell Death
- Angiogenesis
- Oncogenesis
- Cell Motility
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Ubiquitination
- Dephosphorylation
- Acetylation
- Demethylation
- Reduction
- Glycosylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTNNB1
bosterbio.com/bosterbio-gene-info-cards/CTNNB1
References
PMID: 7806582 by Huelsken J., et al. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
PMID: 12019147 by Kim J.-S., et al. Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells.
26 Publications of Boster Catenin beta-1 Antibodies & ELISA Kits
- PubMed ID: 10.7150/jca.49138, LINC00184 involved in the regulatory network of ANGPT2 via ceRNA mediated miR-14...
- PubMed ID: 10.3892/ijo.2018.4564, Histone deacetylase HDAC4 promotes the proliferation and invasion of glioma cell...
- PubMed ID: 10.3892/etm.2018.6430, Bletilla striata polysaccharide has a protective effect on intestinal epithelia...
- PubMed ID: 10.1002/elps.201700143, Novel chemiluminescent Western blot blocking and antibody incubation solution fo...
- PubMed ID: 31171012, Xu C,Liu F,Xiang G,Cao L,Wang S,Liu J,Meng Q,Xu D,Lv S,Jiao J,Niu Y.β-Catenin n...
- PubMed ID: 34090510, Yu D,Zhao Y,Wang H,Kong D,Jin W,Hu Y,Qin Y,Zhang B,Li X,Hao J,Li G,Wang H.IL-1β...
- PubMed ID: 32519176, Piao HY,Guo S,Wang Y,Zhang J.Exosome-transmitted lncRNA PCGEM1 promotes invasive...
- PubMed ID: 18681964, Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis...
- PubMed ID: 26918831, Anti-cancer drug 3, 3%u2032-diindolylmethane activates Wnt4 signaling to enhance...
- PubMed ID: 29250149, Effects of atorvastatin on porcine aqueous humour outflow and trabecular meshwor...
- PubMed ID: 29201165, MgCl2 and ZnCl2 promote human umbilical vein endothelial cell migration and inva...
- PubMed ID: 27279629, Oestrogen and parathyroid hormone alleviate lumbar intervertebral disc degenerat...
- PubMed ID: 27012825, Targeted p53 activation by saRNA suppresses human bladder cancer cells growth an...
- PubMed ID: 26722422, Wnt/?-catenin pathway is required for epithelial to mesenchymal transition in CX...
- PubMed ID: 26677102, Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation o...
- PubMed ID: 25995040, Prolonged overexpression of Wnt10b induces epidermal keratinocyte transformation...
- PubMed ID: 27109829, Naringin ameliorates bone loss induced by sciatic neurectomy and increases Semap...
- PubMed ID: 26793111, Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via S...
- PubMed ID: 25286828, Combination of lithium chloride and pEGFP-N1-BmK CT effectively decreases prolif...
- PubMed ID: 24750467, Modulating hair follicle size with?Wnt10b-DKK1?pair during hair regeneration
- PubMed ID: 29104639, Guo F, Yi X, Li M, Fu J, Li S. Exp Ther Med. 2017 Nov;14(5):4231-4237. doi: 10.3...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page