CSGALNACT1 Antibodies

AND CSGALNACT1 ELISA kits, CSGALNACT1 Proteins

Many biological assays use antibodies to detect CSGALNACT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CSGALNACT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CSGALNACT1 antibodies...

We validate the specificity of these antibodies to CSGALNACT1 by testing them on tissues known to express CSGALNACT1 positively and negatively. Browse below to find the CSGALNACT1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CSGALNACT1 Infographic by Boster Bio

All CSGALNACT1 Products

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Anti-beta-1,4-GalNAc-T CSGALNACT1 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A08025
100ul

CSGALNACT1 Overview

Facts about Chondroitin sulfate N-acetylgalactosaminyltransferase 1.

CSGALNACT1 3D structure. Source: alphafold

Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains.

Important role in chondroitin chain biosynthesis in cartilage formation and following endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity).

Gene Information

Human
Gene Name:	CSGALNACT1
Uniprot:	Q8TDX6
Entrez:	55790

Family

Belongs to:

chondroitin N-acetylgalactosaminyltransferase family

Alternative Names

beta4GalNAcT; beta4GalNAcT-1; ChGn; chondroitin beta1,4 N-acetylgalactosaminyltransferase; Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1; chondroitin sulfate N-acetylgalactosaminyltransferase 1; CSGalNAcT-1; EC 2.4.1.174; FLJ11264; FLJ13760; GALNACT1

Molecular Weight

Mass (kDA):
61.294 kDA

Genomic Context


Human

Location:	8p21.3
Sequence:	8; NC_000008.11 (19404161..19758029, complement)

Tissue Specificity

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

Subcellular Localizations

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Diseases

Multiple Myeloma
Neoplasms
Dwarfism
Malignant Paraganglionic Neoplasm
Liver Regeneration Disorder

Pathways

Cartilage Development
Regeneration
Endochondral Ossification
Cartilage Morphogenesis
Liver Regeneration
Ossification

PTMs

Glycoprotein

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CSGALNACT1

References

PMID: 11788602 by Uyama T., et al. Molecular cloning and expression of human chondroitin N- acetylgalactosaminyltransferase: key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate.

PMID: 12163485 by Gotoh M., et al. Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis.