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- Table of Contents
Facts about CREB/ATF bZIP transcription factor.
Also suppresses the HCFC1- dependent transcriptional activation by CREB3 and lowers the amount of CREB3 from the mobile. Willing to down-regulate expression of some cellular genes in CREBZF-expressing cells.
Human | |
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Gene Name: | CREBZF |
Uniprot: | Q9NS37 |
Entrez: | 58487 |
Belongs to: |
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bZIP family |
CREB/ATF bZIP transcription factor; FLJ94018; HCF-binding transcription factor Zhangfei; Host cell factor-binding transcription factor Zhangfei; SHP-interacting leucine zipper protein; SMILE; Zhangfei
Mass (kDA):
37.134 kDA
Human | |
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Location: | 11q14.1 |
Sequence: | 11; NC_000011.10 (85657985..85682863, complement) |
In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.
Nucleus. Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
PMID: 10871379 by Lu R., et al. Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16.
PMID: 15705566 by Misra V., et al. Zhangfei is a potent and specific inhibitor of the host cell factor- binding transcription factor Luman.