Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.

In response to ER stress, transported to the Golgi, where it is cleaved at a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The published N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.