Protein crumbs homolog 2 Antibodies

AND Crb2 ELISA kits, Protein crumbs homolog 2 Proteins

Many biological assays use antibodies to detect Protein crumbs homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein crumbs homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein crumbs homolog 2 antibodies...

We validate the specificity of these antibodies to Protein crumbs homolog 2 by testing them on tissues known to express Crb2 positively and negatively. Browse below to find the Crb2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Crb2 Infographic by Boster Bio

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Anti-Protein crumbs homolog 2 CRB2 Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A05652
0.1 mg

Crb2 Overview

Facts about Protein crumbs homolog 2.

Protein crumbs homolog 2 (Crb2)

Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) in gastrulation, when newly specified mesodermal cells move inside the embryo (PubMed:26496195, PubMed:27870829). Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer (PubMed:27870829).

The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges specify which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with elevated levels of apical MYH10/myosin-IIB (PubMed:27870829). Also required for maintenance of the apical polarity complex during development of the cortex.

Gene Information

Mouse
Gene Name:	Crb2
Uniprot:	Q80YA8
Entrez:	241324

Family

Belongs to:

Crumbs protein family

Alternative Names

crumbs homolog 2 (Drosophila)

Molecular Weight

Mass (kDA):
134.76 kDA

Genomic Context


Mouse

Location:	2\|2 B
Sequence:	2;

Tissue Specificity

In the adult eye, strongly expressed in the outer nuclear layer, containing the cell bodies of the photoreceptor cells, and in the inner nuclear layer, containing the cell bodies of the horizontal, bipolar, amacrine, and Mueller glial cells (PubMed:15851977). Also expressed in some cells in the ganglion cell layer (or may be displaced amacrine cells rather than ganglion cells) (PubMed:15851977).

Diseases

Amaurosis
Leber Congenital Amaurosis
Retinitis Pigmentosa
Retinal Degeneration
Genomic Instability
Blind Vision
Retinal Dystrophies
Malignant Neoplasms
Malignant Neoplasm Of Ovary
Retinal Diseases
Tissue Adhesions

Dystrophy
Dna Injury
Malignant Neoplasm Of Breast
Nervousness
Eye Diseases, Hereditary
Radiation Induced Dna Damage

Pathways

Dna Damage Checkpoint
Dna Repair
Cell Cycle
Methylation
Cell Cycle Arrest
Localization
Histone Modification
Dna Replication
Histone Lysine Methylation
Mitosis
Cell Death
Cell Adhesion
Telomere Maintenance

Recombinational Repair
S Phase
Pathogenesis
Hyperphosphorylation
Hyphal Growth
Programmed Cell Death
Cell Cycle Phase

PTMs

Phosphorylation
Methylation

Cleavage
Ubiquitination

Gamma-cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Crb2

References

PMID: 15851977 by van den Hurk J.A.J.M., et al. Characterization of the crumbs homolog 2 (CRB2) gene and analysis of its role in retinitis pigmentosa and Leber congenital amaurosis.

PMID: 22072575 by Xiao Z., et al. Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.