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Cpeb4 Antibodies
AND Cpeb4 ELISA kits, Cpeb4 Proteins
Many biological assays use antibodies to detect Cpeb4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cpeb4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cpeb4 antibodies...
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Cpeb4 Infographic by Boster Bio
All Cpeb4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A06139-2
100 μg/vial
Cat # A06139-2
100 μg/vial
Cpeb4 Overview
Facts about Cytoplasmic polyadenylation element-binding protein 4.
Cytoplasmic polyadenylation element-binding protein 4 (Cpeb4)
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') inside the mRNA 3'-UTR (PubMed:17024188). RNA binding causes a clear conformational change similar to the Venus fly trap mechanism (By similarity).
Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by keeping translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (PubMed:28092655). Required for cell cycle progression, especially for cytokinesis and chromosomal segregation (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cpeb4 |
| Uniprot: | Q7TN98 |
| Entrez: | 67579 |
Family
| Belongs to: |
|---|
| RRM CPEB family |
Alternative Names
CPE-binding protein 4; cytoplasmic polyadenylation element binding protein 4; cytoplasmic polyadenylation element-binding protein 4; hCPEB-4; KIAA1673CPE-BP4
Molecular Weight
Mass (kDA):
80.122 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 A4 |
| Sequence: | 11; |
Tissue Specificity
Highly expressed in brain, including hippocampus, amygdala, granule and Purkinje cells of the cerebellum (at protein level) (PubMed:17024188, PubMed:24386439). Expressed in spinal cord (at protein level) (PubMed:27381259). Expressed in kidney, lung and heart (at protein level) (PubMed:12871996, PubMed:27381259, PubMed:24386439). Expressed in liver (at protein level) (PubMed:28092655, PubMed:12871996, PubMed:27381259, PubMed:24386439). Expressed in spleen and testis (at protein level) (PubMed:24386439, PubMed:12871996). Weakly expressed in ovary and in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus (PubMed:12871996).
Diseases
- Malignant Neoplasms
- Tumor Angiogenesis
- Neoplasms
- Cell Invasion
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Brain Ischemia
- Tumor Progression
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Liver
- Sequelae Aspects
- Neoplasm Invasiveness
Pathways
- Translation
- Cell Division
- Angiogenesis
- Cell Migration
- Cell Proliferation
- Cellular Senescence
- Mitosis
- Glycosylation
- M Phase
- Metaphase
- Nuclear Export
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cpeb4
bosterbio.com/bosterbio-gene-info-cards/Cpeb4
References
PMID: 12871996 by Theis M., et al. Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.
PMID: 17024188 by Huang Y.S., et al. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.