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CORIN Antibodies
AND CORIN ELISA kits, CORIN Proteins
Many biological assays use antibodies to detect CORIN, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CORIN in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CORIN antibodies...
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CORIN Infographic by Boster Bio
All CORIN Products
Product
Figures
Specificity
Applications
Price
Human Corin ELISA Kit PicoKine®
1 Citations 8 Q&As
Human
ELISA
$499
Cat # EK1283
96 wells/kit, with removable strips.
Cat # EK1283
96 wells/kit, with removable strips.
CORIN Overview
Facts about Atrial natriuretic peptide-converting enzyme.
Atrial natriuretic peptide-converting enzyme (CORIN)
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA to the active hormone, thereby regulating blood pressure in heart and boosting natriuresis, diuresis and vasodilation.
Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also functions as a regulator of sodium reabsorption in kidney.
Gene Information
| Human | |
|---|---|
| Gene Name: | CORIN |
| Uniprot: | Q9Y5Q5 |
| Entrez: | 10699 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
ATC2; atrial natriuteric peptide-converting enzyme; Corin; corin, serine peptidase; EC 3.4.21; EC 3.4.21.-; heart specific serine proteinase; Heart-specific serine proteinase ATC2; MGC119742; pro-ANP-convertase; Pro-ANP-Converting Enzyme; PRSC; serine protease; Transmembrane protease serine 10
Molecular Weight
Mass (kDA):
116.486 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p12 |
| Sequence: | 4; NC_000004.12 (47593998..47838106, complement) |
Tissue Specificity
Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. May easily detached from the endothelial cell membrane.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Less efficiently targeted to the cell membrane compared to isoform 1.; [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Soluble form produced following cleavage by ADAM10.; [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Soluble form produced following autocatalytic cleavage.; [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: S
Diseases
- Heart Failure
- Hypertensive Disease
- Hypertrophy
- Cardiac Hypertrophy
- Cardiovascular Diseases
- Heart Diseases
- Neoplasms
- Fibrosis
- Malignant Neoplasms
- Decompensated Cardiac Failure
- Osteoarthritis, Knee
- Infarction
- Fracture
Pathways
- Zymogen Activation
- Localization
- Pathogenesis
- Vasodilation
- Secretion
- Diuresis
- Cell Differentiation
- Regulation Of Blood Pressure
- Glycosylation
- Natriuresis
- Excretion
- Hair Follicle Morphogenesis
- Neurogenesis
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CORIN
bosterbio.com/bosterbio-gene-info-cards/CORIN
References
PMID: 10329693 by Yan W., et al. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart.
PMID: 11082206 by Hooper J.D., et al. Localization of the mosaic transmembrane serine protease corin to heart myocytes.
1 Publications of Boster CORIN Antibodies & ELISA Kits
- PubMed ID: -, Liu M,Wang RB,Xing JH,Tang YX.Nested Case–Control Study of Corin Combined with...
*More publications can be found for each product on its corresponding product page