COQ8A Antibodies

AND COQ8A ELISA kits, COQ8A Proteins

Many biological assays use antibodies to detect COQ8A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COQ8A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COQ8A antibodies...

We validate the specificity of these antibodies to COQ8A by testing them on tissues known to express COQ8A positively and negatively. Browse below to find the COQ8A antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COQ8A Infographic by Boster Bio

All COQ8A Products

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Product

Figures

Specificity

Applications

Price

Anti-ADCK3 (N323) COQ8A Antibody

Human, Mouse, Rat

$405
Cat # A32273
100ul

Anti-CABC1 COQ8A Antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A32273-1
100ul

Anti-ADCK3 (COQ8A) Mouse Monoclonal Antibody [Clone ID: OTI2A7]

Human

$523
Cat # M32273
100 µl

ADCK3 (COQ8A) (NM_020247) Human Over-expression Lysate

Human

$628
Cat # LS056997
100 µg

COQ8A Overview

Facts about Atypical kinase COQ8A, mitochondrial.

COQ8A 3D structure. Source: alphafold

Atypical kinase COQ8A, mitochondrial (COQ8A)

Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not reveal any protein kinase activity (PubMed:25498144, PubMed:27499294).

Probably acts as a small molecule kinase, maybe a lipid kinase that phosphorylates a prenyl lipid from the ubiquinone biosynthesis pathway, as indicated by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).

Gene Information

Human
Gene Name:	COQ8A
Uniprot:	Q8NI60
Entrez:	56997

Family

Belongs to:

protein kinase superfamily

Alternative Names

Atypical kinase COQ8A, mitochondrial

Molecular Weight

Mass (kDA):
71.95 kDA

Genomic Context


Human

Location:	1q42.13
Sequence:	1; NC_000001.11 (226939339..226987544)

Tissue Specificity

Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.

Subcellular Localizations

Mitochondrion. Membrane; Single-pass membrane protein.

Diseases

Coenzyme Q10 deficiency, primary, 4 (COQ10D4)

Interacting Proteins

AGTRAP
COQ9
DTX2
RABAC1
REEP6

SH3GLB1
TFIP11
TMEM159
TMEM239

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COQ8A

References

PMID: 11888884 by Iiizumi M., et al. Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex.

PMID: 25498144 by Stefely J.A., et al. Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.