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- Table of Contents
Facts about Coatomer subunit beta'.
In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). .
Human | |
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Gene Name: | COPB2 |
Uniprot: | P35606 |
Entrez: | 9276 |
Belongs to: |
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WD repeat COPB2 family |
beta prime subunit; Beta'-coat protein; Beta'-COP; betaprime-COP; coatomer protein complex, subunit beta 2 (beta prime); coatomer subunit beta'; p102
Mass (kDA):
102.487 kDA
Human | |
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Location: | 3q23 |
Sequence: | 3; NC_000003.12 (139355595..139389680, complement) |
Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi.
PMID: 8335000 by Harrison-Lavoie K.J., et al. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins.
PMID: 25129144 by Boztug K., et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia.