G-protein coupled receptor 37-like 1 (GPR37L1)

G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594).

However, other studies have shown that prosaposin doesn't increase action (PubMed:27072655, PubMed:28688853). It's been suggested that GPR37L1 is a constitutively active receptor that signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655).