COL4A4 Antibodies

AND COL4A4 ELISA kits, COL4A4 Proteins

Many biological assays use antibodies to detect COL4A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL4A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL4A4 antibodies...

We validate the specificity of these antibodies to COL4A4 by testing them on tissues known to express COL4A4 positively and negatively. Browse below to find the COL4A4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COL4A4 Infographic by Boster Bio

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Anti-Collagen alpha-4(IV) chain COL4A4 Antibody

Human

ELISA, IF, IHC

$380
Cat # A02908
100ul

COL4A4 Overview

Facts about Collagen alpha-4(IV) chain.

COL4A4 3D structure. Source: alphafold

Collagen alpha-4(IV) chain (COL4A4)

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. .

Gene Information

Human
Gene Name:	COL4A4
Uniprot:	P53420
Entrez:	1286

Family

Belongs to:

type IV collagen family

Alternative Names

Collagen alpha-4(IV) chain

Molecular Weight

Mass (kDA):
164.038 kDA

Genomic Context


Human

Location:	2q36.3
Sequence:	2; NC_000002.12 (226970293..227164482, complement)

Tissue Specificity

Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. Highest levels of expression of alpha 4 type IV collagen are detected in kidney, calvaria, neuroretina and cardiac muscle. Lower levels of expression are observed in brain, lung and thymus, and no expression is detected in choroid plexus, liver, adrenal, pancreas, ileum or skin.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix, basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).

Diseases

Alport syndrome 2, autosomal recessive (ATS2)

PTMs

Disulfide bond

Glycoprotein

Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL4A4

References

PMID: 7523402 by Leinonen A., et al. Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains.

PMID: 9792860 by Boye E., et al. Determination of the genomic structure of the COL4A4 gene and of novel mutations causing autosomal recessive Alport syndrome.