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COL4A3 Antibodies
AND COL4A3 ELISA kits, COL4A3 Proteins
Many biological assays use antibodies to detect COL4A3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL4A3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL4A3 antibodies...
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COL4A3 Overview
Facts about Collagen alpha-3(IV) chain.
Collagen alpha-3(IV) chain (COL4A3)
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. .
Gene Information
| Human | |
|---|---|
| Gene Name: | COL4A3 |
| Uniprot: | Q01955 |
| Entrez: | 1285 |
Family
| Belongs to: |
|---|
| type IV collagen family |
Alternative Names
COL4A3; collagen alpha-3(IV) chain; collagen IV, alpha-3 polypeptide; collagen, type IV, alpha 3 (Goodpasture antigen); Goodpasture antigen; Tumstatin
Molecular Weight
Mass (kDA):
161.813 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q36.3 |
| Sequence: | 2; NC_000002.12 (227164589..227314792) |
Tissue Specificity
Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression of alpha 3 and alpha 4 type IV collagens in kidney, but PubMed:7523402 reports that in kidney levels of alpha 3 type IV collagen are significantly lower than those of alpha 4 type IV collagen. According to PubMed:8083201, alpha 3 type IV collagen is not detected in heart, brain, placenta, liver, pancreas, extrasynaptic muscle fibers, endoneurial and perineurial nerves, fetal brain, fetal heart and fetal liver. According to PubMed:7523402, alpha 3 type IV collagen is strongly expressed in pancreas, neuroretina and calvaria and not expressed in adrenal, ileum and skin. Isoform 1 and isoform 3 are strongly expressed in kidney, lung, suprarenal capsule, muscle and spleen, in each of these tissues isoform 1 is more abundant than isoform 3. Isoform 1 and isoform 3 are expressed at low levels in artery, fat, pericardium and peripherical nerve, but not in placenta, mesangium, skin, pleura and cultured umbilical endothelial cells.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix, basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).
Diseases
- Hereditary Nephritis
- Kidney Diseases
- Kidney Failure
- Glioblastoma
- Kidney Failure, Chronic
- Proteinuria Of Undiagnosed Cause
- Thin Basement Membrane Disease
- Nephritis
- Familial Hematuria
- Alport Syndrome, X-linked
- Complete Hearing Loss
- Glomerulonephritis
- Benign Familial Haematuria
Pathways
- Pathogenesis
- Glomerular Filtration
- Localization
- Cell Proliferation
- Angiogenesis
- Cell Adhesion
- Cell Migration
- Cellular Senescence
- Complement Activation
- Sex Determination
- Ossification
- Endothelial Cell Proliferation
- Cell Maturation
PTMs
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL4A3
bosterbio.com/bosterbio-gene-info-cards/COL4A3
References
PMID: 8083201 by Mariyama M., et al. Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues.
PMID: 11134255 by Heidet L., et al. Structure of the human type IV collagen gene COL4A3 and mutations in autosomal Alport syndrome.